Evidence map›Paper›PMID 24429832›Full record

ArticleHistochemistry and cell biology2014

Use of halogenated precursors to define a transcription time window after treatment with hypometabolizing molecules.

Alessandro Spedito, Barbara Cisterna, Manuela Malatesta, Marco Biggiogera

Abstract read
PubMed Publisher
In one paragraph

Article in Histochemistry and cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Perichromatin region: a moveable feast.Histochemistry and cell biology · 2018
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alessandro SpeditoDipartimento di Biologia e Biotecnologie, Laboratorio di Biologia Cellulare e Neurobiologia, Università degli Studi di Pavia, Via Ferrata 1, Pavia, Italy.
Barbara Cisterna
Manuela Malatesta
Marco Biggiogera
University of Pavia · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new method is proposed which combines the high spatial resolution of transmission electron microscopy with information on the dynamics of transcription. Incorporation of two different RNA precursors was used to define a time transcription window on cultured cells treated with hypometabolizing peptides which are known to modulate transcription. This procedure allows detecting a single fibril of newly synthesized RNA in the time range in which it is transcribed.

Indexed as

Cell Line, TumorCell NucleusCell ProliferationDactinomycinDichlororibofuranosylbenzimidazoleEnkephalin, Leucine-2-AlanineHeLa CellsHumansImmunohistochemistryMicroscopy, Electron, TransmissionRNA PrecursorsRNA, RibosomalStaining and LabelingTranscription, GeneticUridineDactinomycinDichlororibofuranosylbenzimidazoleEnkephalin, Leucine-2-AlanineRNA PrecursorsRNA, RibosomalUridine

Identifiers

PMID24429832
OpenAlexW2029215500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.