ArticleScientific reports2014
Network understanding of herb medicine via rapid identification of ingredient-target interactions.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Targeted inhibition of Nrf2 potentiates antitumor immunity and enhances the efficacy of immunotherapy in hepatocellular carcinoma.Journal for immunotherapy of cancer · 2026Article
- Uses of Molecular Docking Simulations in Elucidating Synergistic, Additive, and/or Multi-Target (SAM) Effects of Herbal Medicines.Molecules (Basel, Switzerland) · 2024Review
- The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.Frontiers in pharmacology · 2020Article
- Evaluation of the combinatorial effect of3 Biotech · 2019Article
- Brusatol, an NRF2 inhibitor for future cancer therapeutic.Cell & bioscience · 2019Article
- Heterogeneous network propagation for herb target identification.BMC medical informatics and decision making · 2018Article
- In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.International journal of molecular sciences · 2016Article
- System analysis of LWDH related genes based on text mining in biological networks.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Today, herb medicines have become the major source for discovery of novel agents in countermining diseases. However, many of them are largely under-explored in pharmacology due to the limitation of current experimental approaches. Therefore, we proposed a computational framework in this study for network understanding of herb pharmacology via rapid identification of putative ingredient-target interactions in human structural proteome level. A marketing anti-cancer herb medicine in China, Yadanzi (Brucea javanica), was chosen for mechanistic study. Total 7,119 ingredient-target interactions were identified for thirteen Yadanzi active ingredients. Among them, about 29.5% were estimated to have better binding affinity than their corresponding marketing drug-target interactions. Further Bioinformatics analyses suggest that simultaneous manipulation of multiple proteins in the MAPK signaling pathway and the phosphorylation process of anti-apoptosis may largely answer for Yadanzi against non-small cell lung cancers. In summary, our strategy provides an efficient however economic solution for systematic understanding of herbs' power.
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