ArticleAmerican journal of hypertension2014
Autocrine and paracrine function of Angiotensin 1-7 in tissue repair during hypertension.
Article in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The ACE2/Ang-(1-7)/MasR axis alleviates brain injury after cardiopulmonary resuscitation in rabbits by activating PI3K/Akt signaling.Translational neuroscience · 2024Article
- Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases.Cell cycle (Georgetown, Tex.) · 2023Review
- Hypotension as a marker or mediator of perioperative organ injury: a narrative review.British journal of anaesthesia · 2022Review
- Estradiol Supplement or Induced Hypertension May Attenuate the Angiotensin II Type 1 Receptor Antagonist-Promoted Renal Blood Flow Response to Graded Angiotensin II Administration in Ovariectomized Rats.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022Article
- An Updated Review on Complicated Mechanisms of COVID-19 Pathogenesis and Therapy: Direct Viral Damage, Renin-angiotensin System Dysregulation, Immune System Derangements, and Endothelial Dysfunction.Infectious disorders drug targets · 2022Article
- Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury.American journal of physiology. Lung cellular and molecular physiology · 2020Review
- Article
- Molecular and Cellular Effect of Angiotensin 1-7 on Hypertensive Kidney Disease.American journal of hypertension · 2019Article
- Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury.Frontiers in cardiovascular medicine · 2019Article
- Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II.Scientific reports · 2018Article
- Angiotensin-(1-7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis.Current hypertension reports · 2018Review
- The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).Physiological reviews · 2018Review
- Ang-(1-7) is an endogenous β-arrestin-biased agonist of the ATScientific reports · 2017Article
- Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways.Journal of cell signaling · 2017Article
- Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.American journal of hypertension · 2016Article
- Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats.Journal of cellular and molecular medicine · 2015Article
- Article
- Article
- The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling.International journal of inflammation · 2014Review
- From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAngiotensin-converting enzyme 2 (ACE2) cleaves angiotensin (Ang) II to generate Ang1-7, which mediates cellular actions through Mas receptors (MasR). Hypertension is accompanied by high or low circulating AngII levels and cardiac/renal injury. The purpose of this study is to explore (i) whether circulating AngII affects ACE2/MasR expressions in the hypertensive heart and kidney; and (ii) whether Ang1-7 regulates cardiac repair/remodeling responses through MasR during hypertension.
methodsIn the first portion of the study, rats received either an AngII infusion (400ng/kg/min) for 4 weeks, leading to hypertension with high circulating AngII, or an aldosterone (ALDO, 0.75 μg/h) infusion for 4 weeks, leading to hypertension with low/normal circulating AngII. Cardiac and renal ACE2/MasR expressions were examined. We found that cardiac ACE2 was increased and MasR attenuated in both AngII and ALDO groups. However, renal ACE2 and MasR remained unchanged in both AngII- and ALDO-treated animals.
resultsIn the second portion, rats received AngII infusion with/without MasR antagonist (A779, 1mg/kg/day) for 4 weeks. The roles of MasR blockade in cardiac inflammation, fibrosis, apoptosis, and ventricular function were examined. Chronic AngII infusion caused scattered cardiac injuries, and A779 cotreatment exacerbated cardiac injury, resulting in aggravated inflammatory, fibrogenic, and apoptotic responses compared with the AngII group. Cardiac function, however, was unaltered in the AngII and A779 groups.
conclusionsACE2 and MasR expressions in the hypertensive heart and kidney are not regulated by circulating AngII levels. Ang1-7 is involved in multiple repair responses, suggesting that therapeutic strategies aimed at administering Ang1-7 hold potential for the management of cardiac remodeling.
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