Evidence map›Paper›PMID 24429673›Full record

ArticleScientific reports2014

Engineering the heart: evaluation of conductive nanomaterials for improving implant integration and cardiac function.

Jin Zhou, Jun Chen, Hongyu Sun, Xiaozhong Qiu, Yongchao Mou, Zhiqiang Liu, Yuwei Zhao, Xia Li, Yao Han, Cuimi Duan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Review
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Advances in Cardiac Tissue Engineering.Bioengineering (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. 2D Materials for Cardiac Tissue Repair and Regeneration.Frontiers in cardiovascular medicine · 2022
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jin Zhou1] Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China [2].
Jun Chen1] Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada [2].
Hongyu Sun1] Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China [2].
Xiaozhong Qiu1] Department of Anatomy, Southern Medical University, Guangzhou Guangdong, China [2].
Yongchao MouDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Zhiqiang LiuDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Yuwei ZhaoDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Xia LiDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Yao HanDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Cuimi DuanDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Rongyu TangDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Chunlan WangDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
Wen ZhongDepartment of Textile Sciences, Faculty of Human Ecology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada.
Jie LiuDepartment of Biomedical Engineering, College of Engineering, 5 Yiheyuan Rd, Peking University, HaidianDist, Beijing, China.
Ying LuoDepartment of Biomedical Engineering, College of Engineering, 5 Yiheyuan Rd, Peking University, HaidianDist, Beijing, China.
Malcolm Mengqiu XingDepartment of Mechanical and Manufacturing Engineering, Faculty of Engineering, Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
Changyong WangDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated a paradigm to construct ECTs for cardiac repair using conductive nanomaterials. Single walled carbon nanotubes (SWNTs) were incorporated into gelatin hydrogel scaffolds to construct three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment in vitro favorable for cardiac contraction and the expression of electrochemical associated proteins. Upon implantation into the infarct hearts in rats, ECTs structurally integrated with the host myocardium, with different types of cells observed to mutually invade into implants and host tissues. The functional measurements showed that SWNTs were essential to improve the performance of ECTs in inhibiting pathological deterioration of myocardium. This work suggested that conductive nanomaterials hold therapeutic potential in engineering cardiac tissues to repair myocardial infarction.

Indexed as

MyocardiumTissue EngineeringAnimalsBiocompatible MaterialsDisease Models, AnimalGelatinHeartHydrogel, Polyethylene Glycol DimethacrylateMaleMaterials TestingMyocardial InfarctionNanostructuresNanotubes, CarbonProstheses and ImplantsRatsTissue ScaffoldsBiocompatible MaterialsGelatinHydrogel, Polyethylene Glycol DimethacrylateNanotubes, Carbon

Identifiers

PMID24429673
PMCPMC3893643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.