ArticleGenetics2014
The rate of adaptation in large sexual populations with linear chromosomes.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population.eLife · 2025Article
- Ecological diversification in rapidly evolving populations.bioRxiv : the preprint server for biology · 2025Article
- Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population.bioRxiv : the preprint server for biology · 2025Article
- Article
- Human deleterious mutation rate slows adaptation and implies high fitness variance.bioRxiv : the preprint server for biology · 2025Article
- Selection Can Favor a Recombination Landscape That Limits Polygenic Adaptation.Molecular biology and evolution · 2025Article
- Evolution of evolvability in rapidly adapting populations.Nature ecology & evolution · 2024Article
- Long-range linkage effects in adapting sexual populations.Scientific reports · 2023Article
- Article
- Evolution of resistance under alternative models of selective interference.Journal of evolutionary biology · 2021Article
- Survival of the simplest in microbial evolution.Nature communications · 2019Article
- The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.Genetics · 2019Article
- Directional Selection Rather Than Functional Constraints Can Shape the G Matrix in Rapidly Adapting Asexuals.Genetics · 2019Article
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- Article
- Effective models and the search for quantitative principles in microbial evolution.Current opinion in microbiology · 2018Review
- Article
- Recombination Alters the Dynamics of Adaptation on Standing Variation in Laboratory Yeast Populations.Molecular biology and evolution · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked alleles may still greatly interfere with each other. We show for well-mixed populations that when this interference is strong, the genome can be seen as consisting of many effectively asexual stretches linked together. The rate at which beneficial alleles fix is thus roughly proportional to the rate of recombination and depends only logarithmically on the mutation supply and the strength of selection. Our scaling arguments also allow us to predict, with reasonable accuracy, the fitness distribution of fixed mutations when the mutational effect sizes are broad. We focus on the regime in which crossovers occur more frequently than beneficial mutations, as is likely to be the case for many natural populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.