ArticleBMC pregnancy and childbirth2014
The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study.
Article in BMC pregnancy and childbirth, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 225 citations in OpenAlex.
- Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022 · on this mapPooled it
- Maternal and birth cohort studies in the Gulf Cooperation Council countries: a systematic review and meta-analysis.Systematic reviews · 2020Pooled it
- Mediating effect of gestational weight gain on the preventive effect of exercise during pregnancy on macrosomia: a randomized clinical trial.BMC pregnancy and childbirth · 2024Trial
- Flash glucose monitoring in gestational diabetes mellitus (FLAMINGO): a randomised controlled trial.Acta diabetologica · 2023Trial
- Prepregnancy body mass index and gestational weight gain are associated with maternal and infant adverse outcomes in Chinese women with gestational diabetes.Scientific reports · 2022Trial
- Early Childhood Obesity: Multifactorial Influences with a Prominent Familial ContributionJournal of clinical research in pediatric endocrinology · 2026Article
- Differences in association between gestational weight gain and perinatal outcomes according to pre-pregnancy body mass index categories and gestational diabetes mellitus status: findings from a large Japanese cohort.BMJ open diabetes research & care · 2026Article
- Nonlinear association between birth weight and overweight/obesity in children aged 3-6 years: a retrospective analysis of 13 cities in China.Frontiers in nutrition · 2026Article
- Adverse Pregnancy Outcomes in Women with Gestational Diabetes Using Different Diagnostic Criteria: A Study from the Northern Adriatic Region of Croatia.Medicina (Kaunas, Lithuania) · 2025Article
- Which dietary pattern should be adopt by age-appropriate pregnant women to avoid gestational weight gain and gestational diabetes mellitus.BMC pregnancy and childbirth · 2025Article
- Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria.BMC pediatrics · 2025Article
- The association of maternal pre-pregnancy body mass index with macrosomia: a birth cohort study from China.PeerJ · 2025Article
- Factors associated with Macrosomia in public hospitals of Mekelle City, Northern Ethiopia: A multi-center study.PloS one · 2025Article
- Genetic Insights Into Perinatal Outcomes of Maternal Antihypertensive Therapy During Pregnancy.JAMA network open · 2024Article
- The Relationship between Birth Weight and the Risk of Overweight and Obesity among Chinese Children and Adolescents Aged 7-17 Years.Nutrients · 2024Article
- Maternal Height Is an Independent Risk of Adverse Outcomes in Women with Gestational Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Associations of COVID-19 lockdown with birth weight in China.Frontiers in pediatrics · 2024Article
- Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study.Frontiers in medicine · 2024Article
- Improvement effect of insulin resistance in one-day outpatient service by reducing stress adaptation disorders in patients with gestational diabetes mellitus.Frontiers in nutrition · 2024Article
- Inappropriate gestational weight gain impact on maternofetal outcomes in gestational diabetes.Annals of medicine · 2023Article
27 more citing papers are in PubMed but not listed here.
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10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is crucial to identify in large population samples the most important determinants of excessive fetal growth. The aim of the study was to evaluate the independent role of pre-pregnancy body mass index (BMI), gestational weight gain and gestational diabetes on the risk of macrosomia.
methodsA prospective study collected data on mode of delivery and maternal/neonatal outcomes in eleven Hospitals in Italy. Multiple pregnancies and preterm deliveries were excluded. The sample included 14109 women with complete records. Associations between exposure variables and newborn macrosomia were analyzed using Pearson's chi squared test. Multiple logistic regression models were built to assess the independent association between potential predictors and macrosomia.
resultsMaternal obesity (adjusted OR 1.7, 95% CI 1.4-2.2), excessive gestational weight gain (adjusted OR 1.9, 95% CI 1.6-2.2) and diabetes (adjusted OR 2.1, 95% CI 1.5-3.0 for gestational; adjusted OR 3.0, 95% CI 1.2-7.6 for pre-gestational) resulted to be independent predictors of macrosomia, when adjusted for other recognized risk factors. Since no significant interaction was found between pre-gestational BMI and gestational weight gain, excessive weight gain should be considered an independent risk factor for macrosomia. In the sub-group of women affected by gestational or pre-gestational diabetes, pre-gestational BMI was not significantly associated to macrosomia, while excessive pregnancy weight gain, maternal height and gestational age at delivery were significantly associated. In this sub-population, pregnancy weight gain less than recommended was not significantly associated to a reduction in macrosomia.
conclusionsOur findings indicate that maternal obesity, gestational weight gain excess and diabetes should be considered as independent risk factors for newborn macrosomia. To adequately evaluate the clinical evolution of pregnancy all three variables need to be carefully assessed and monitored.
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