ArticleParasites & vectors2014
Distribution and dissemination of the Val1016Ile and Phe1534Cys Kdr mutations in Aedes aegypti Brazilian natural populations.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed, 171 citations in OpenAlex.
- Insecticide susceptibility and knockdown resistance (Kdr) mutations (F1534C and V1016I) in Aedes aegypti populations from Dar es Salaam, Tanzania.Parasites & vectors · 2026Article
- Pyrethroids and organophosphate resistance in Aedes aegypti (Diptera: Culicidae) and their underlying mechanisms.Parasites & vectors · 2026Article
- Rising of pyrethroid resistance mutations (kdr) in the dengue vectorFrontiers in public health · 2026Article
- Evidence of insecticide resistance in Aedes aegypti populations of Suriname: first report of malathion resistance and presence of the kdr mutations V410L, V1016I and F1534C.Memorias do Instituto Oswaldo Cruz · 2026Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- First report of the pyrethroid-resistance-associated V1016I mutation in Aedes aegypti at the seaport of Cotonou, Benin, West Africa.Tropical medicine and health · 2025Article
- Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.Parasites & vectors · 2025Review
- Invasion of the Dengue Vector Aedes albopictus in the Port City of Takoradi, Southwestern Ghana.Research square · 2025Article
- Insecticide resistance status and high frequency of kdr mutations in Aedes aegypti in Tegucigalpa, Honduras.Parasites & vectors · 2025Article
- Systematic Review of the Ovitrap Surveillance ofTropical medicine and infectious disease · 2025Review
- High voltage-gated sodium channel gene diversity in Aedes albopictus across Brazil.Scientific reports · 2025Article
- Article
- Insecticide resistance dynamics inGigaByte (Hong Kong, China) · 2025Article
- Understanding the Global Dynamics of Pyrethroid Resistance-relatedZoological studies · 2025Article
- A unique mechanism of transfluthrin action revealed by mapping its binding sites in the mosquito sodium channel.Insect biochemistry and molecular biology · 2024Article
- Organophosphate and Pyrethroid Resistance Status of InvasiveJournal of arthropod-borne diseases · 2024Article
- Insecticide resistance status and mechanisms in Aedes aegypti and Aedes albopictus from different dengue endemic regions of Panama.Tropical medicine and health · 2024Article
- First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence.Parasites & vectors · 2024Article
- Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran.Parasites & vectors · 2024Article
- Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti.PloS one · 2024Article
53 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe chemical control of the mosquito Aedes aegypti, the major vector of dengue, is being seriously threatened due to the development of pyrethroid resistance. Substitutions in the 1016 and 1534 sites of the voltage gated sodium channel (AaNaV), commonly known as kdr mutations, confer the mosquito with knockdown resistance. Our aim was to evaluate the allelic composition of natural populations of Brazilian Ae. aegypti at both kdr sites.
methodsThe AaNaV IIIS6 region was cloned and sequenced from three Brazilian populations. Additionally, individual mosquitoes from 30 populations throughout the country were genotyped for 1016 and 1534 sites, based in allele-specific PCR. For individual genotypes both sites were considered as a single locus.
resultsThe 350 bp sequence spanning the IIIS6 region of the AaNaV gene revealed the occurrence of the kdr mutation Phe1534Cys in Brazil. Concerning the individual genotyping, beyond the susceptible wild-type (NaVS), two kdr alleles were identified: substitutions restricted to the 1534 position (NaVR1) or simultaneous substitutions in both 1016 and 1534 sites (NaVR2). A clear regional distribution pattern of these alleles was observed. The NaVR1kdr allele occurred in all localities, while NaVR2 was more frequent in the Central and Southeastern localities. Locations that were sampled multiple times in the course of a decade revealed an increase in frequency of the kdr mutations, mainly the double mutant allele NaVR2. Recent samples also indicate that NaVR2 is spreading towards the Northern region.
conclusionsWe have found that in addition to the previously reported Val1016Ile kdr mutation, the Phe1534Cys mutation also occurs in Brazil. Allelic composition at both sites was important to elucidate the actual distribution of kdr mutations throughout the country. Studies to determine gene flow and the fitness costs of these kdr alleles are underway and will be important to better understand the dynamics of Ae. aegypti pyrethroid resistance.
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