Trial reportPain research & management
Impaired modulation of pain in patients with postherpetic neuralgia.
Trial report in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Quantitative sensory testing of pain in osteoporosis: a pilot randomized clinical trial with magnesium supplementation.Aging clinical and experimental research · 2026Trial
- Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study.Drug design, development and therapy · 2018Trial
- Memantine before Mastectomy Prevents Post-Surgery Pain: A Randomized, Blinded Clinical Trial in Surgical Patients.PloS one · 2016Trial
- Trial
- Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial.Trials · 2014Trial
- Exclusion criteria in clinical trials of treatments for neuropathic pain: a systematic analysis.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Conditioned Pain Modulation, Placebo and Offset Analgesia: Rates of Behavioural Expression of Inhibitory, Nonresponse and Facilitatory Pain Modulatory Effects.European journal of pain (London, England) · 2025Article
- The effect of expectancy on conditioned pain modulation: evidence from functional near-infrared spectroscopy.Frontiers in psychology · 2025Article
- Conditioned pain modulation (CPM) paradigm type affects its sensitivity as a biomarker of fibromyalgia.Scientific reports · 2024Article
- A randomised sham-controlled study evaluating rTMS analgesic efficacy for postherpetic neuralgia.Frontiers in neuroscience · 2023Article
- Anti- and Pro-Nociceptive mechanisms in neuropathic pain after human spinal cord injury.European journal of pain (London, England) · 2022Article
- Painful Cutaneous Electrical Stimulation vs. Heat Pain as Test Stimuli in Conditioned Pain Modulation.Brain sciences · 2020Article
- Article
- Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain.International review of neurobiology · 2018Review
- Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome.PloS one · 2017Article
- Localized neuropathic pain: an expert consensus on local treatments.Drug design, development and therapy · 2017Review
- Article
- Observational
- Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective.Therapeutic advances in vaccines · 2015Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe efficiency of inhibitory pain descending pathways (evaluated using conditioned pain modulation [CPM]) has not been studied in postherpetic neuralgia (PHN).
objectiveTo compare CPM in PHN patients with healthy controls.
methodsNine PHN patients and nine control individuals were matched according to age and sex. Amplitudes of cortical thermal-evoked potentials were recorded on the surface of the scalp; clinical pain and thermal pain were evaluated on a 0 to 10 numerical rating scale, at baseline and at intervals during the 6 min after CPM (elicited by a cold pressor test, 8°C). A battery of cognitive tests was performed. Amplitude differences, percentages and related areas under the curve (AUC<span style="vertical-align: sub">CPM<⁄span>) were calculated and all data were compared between both groups; P<0.05 was considered to be statistically significant.
resultsAUC<span style="vertical-align: sub">CPM0-6 min<⁄span> was significantly lower in PHN patients compared with controls (-39±51 µV⁄min versus -144±66 µV⁄min; P=0.0012) and correlated (P=0.04) with clinical pain intensity. Pain ratings before CPM were similar in both groups but were significantly lower in the control group 3 min after the cold pressor test. Cognitive test results were not significantly different.
conclusionPsychophysical and electrophysiological approaches have shown that patients with PHN exhibit a deficiency of pain inhibition modulation, which could signal a predisposing factor to developing chronic pain. This deficiency was not linked to the cognitive performance but rather to subtle in situ cognitivoemotional adaptations, which remain to be investigated.
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