ArticleInterface focus2013
A vision and strategy for the virtual physiological human: 2012 update.
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.Nature methods · 2025Article
- Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage.bioRxiv : the preprint server for biology · 2024Article
- Article
- Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example.Translational psychiatry · 2021Review
- High fidelity blood flow in a patient-specific arteriovenous fistula.Scientific reports · 2021Article
- Towards blood flow in the virtual human: efficient self-coupling of HemeLB.Interface focus · 2021Article
- Personalized whole-body models integrate metabolism, physiology, and the gut microbiome.Molecular systems biology · 2020Article
- Impact of predictive medicine on therapeutic decision making: a randomized controlled trial in congenital heart disease.NPJ digital medicine · 2019Article
- Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.Biomedical engineering online · 2018Review
- CropsFrontiers in plant science · 2017Article
- Using physiologically based models for clinical translation: predictive modelling, data interpretation or something in-between?The Journal of physiology · 2016Review
- A perspective on bridging scales and design of models using low-dimensional manifolds and data-driven model inference.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- The new holism: P4 systems medicine and the medicalization of health and life itself.Medicine, health care, and philosophy · 2016Article
- Participatory medicine: model based tools for engaging and empowering the individual.Interface focus · 2016Article
- Integration of advances in social media and mHealth technology are pivotal to successful cancer prevention and control.mHealth · 2016Review
- Computational fluid dynamics modelling in cardiovascular medicine.Heart (British Cardiac Society) · 2016Review
- Virtual Patients in a Behavioral Medicine Massive Open Online Course (MOOC): A Case-Based Analysis of Technical Capacity and User Navigation Pathways.JMIR medical education · 2015Article
- Implementation of a model of bodily fluids regulation.Acta biotheoretica · 2015Article
- A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.