Evidence map›Paper›PMID 24427534›Full record

ArticleInterface focus2013

Impact of blood rheology on wall shear stress in a model of the middle cerebral artery.

Miguel O Bernabeu, Rupert W Nash, Derek Groen, Hywel B Carver, James Hetherington, Timm Krüger, Peter V Coveney

Abstract read
In one paragraph

Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Frontiers in bioengineering and biotechnology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miguel O BernabeuCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK ; CoMPLEX , University College London , Physics Building, Gower Street, London WC1E 6BT , UK.
Rupert W NashCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK.
Derek GroenCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK.
Hywel B CarverCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK ; CoMPLEX , University College London , Physics Building, Gower Street, London WC1E 6BT , UK.
James HetheringtonResearch Software Development Team, Research Computing and Facilitating Services , University College London , Podium Building, 1st Floor, Gower Street, London WC1E 6BT , UK.
Timm KrügerCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK.
Peter V CoveneyCentre for Computational Science, Department of Chemistry , University College London , 20 Gordon Street, London WC1H 0AJ , UK.

Funding

Medical Research Council MR/K006584/1
6 · The paper itself

Abstract

Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies, including intracranial aneurysms and atherosclerosis. Recent computational work suggests that, in order to correctly characterize such forces, the shear-thinning properties of blood must be taken into account. To the best of our knowledge, these findings have never been compared against experimentally observed pathological thresholds. In this work, we apply the three-band diagram (TBD) analysis due to Gizzi et al. (Gizzi et al. 2011 Three-band decomposition analysis of wall shear stress in pulsatile flows. Phys. Rev. E 83, 031902. (doi:10.1103/PhysRevE.83.031902)) to assess the impact of the choice of blood rheology model on a computational model of the right middle cerebral artery. Our results show that, in the model under study, the differences between the wall shear stress predicted by a Newtonian model and the well-known Carreau-Yasuda generalized Newtonian model are only significant if the vascular pathology under study is associated with a pathological threshold in the range 0.94-1.56 Pa, where the results of the TBD analysis of the rheology models considered differs. Otherwise, we observe no significant differences.

Indexed as

blood flow modellinglattice Boltzmannmulti-scale modellingrheologythree-band diagram analysis

Identifiers

PMID24427534
PMCPMC3638489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.