ArticleInterface focus2013
Where do the platelets go? A simulation study of fully resolved blood flow through aneurysmal vessels.
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Intradimer forces and their implication for conformations of von Willebrand factor multimers.Biophysical journal · 2021Article
- Digital blood in massively parallel CPU/GPU systems for the study of platelet transport.Interface focus · 2021Article
- Predictive modelling of thrombus formation in diabetic retinal microaneurysms.Royal Society open science · 2020Article
- Computational and experimental investigation of particulate matter deposition in cerebral side aneurysms.Journal of the Royal Society, Interface · 2020Article
- A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.PLoS computational biology · 2020Article
- Cell-resolved blood flow simulations of saccular aneurysms: effects of pulsatility and aspect ratio.Journal of the Royal Society, Interface · 2018Article
- Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.Biophysical journal · 2018Article
- Method for the simulation of blood platelet shape and its evolution during activation.PLoS computational biology · 2018Article
- Validation of Patient-Specific Cerebral Blood Flow Simulation Using Transcranial Doppler Measurements.Frontiers in physiology · 2018Article
- A cell-based mechanical model of coronary artery tunica media.Journal of the Royal Society, Interface · 2017Article
- A physical description of the adhesion and aggregation of platelets.Royal Society open science · 2017Article
- A General Shear-Dependent Model for Thrombus Formation.PLoS computational biology · 2017Article
- Towards the virtual artery: a multiscale model for vascular physiology at the physics-chemistry-biology interface.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Strongly Accelerated Margination of Active Particles in Blood Flow.Biophysical journal · 2016Article
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of platelets in the formation of a thrombus, their transport in complex flows has not yet been studied in detail. In this paper we simulated red blood cells and platelets to explore their transport behaviour in aneurysmal geometries. We considered two aneurysms with different aspect ratios (AR = 1.0, 2.0) in the presence of fast and slow blood flows (Re = 10, 100), and examined the distributions of the cells. Low velocities in the parent vessel resulted in a large stagnation zone inside the cavity, leaving the initial distribution almost unchanged. In fast flows, an influx of platelets into the aneurysm was observed, leading to an elevated concentration. The connection of the platelet-rich cell-free layer (CFL) with the outer regions of the recirculation zones leads to their increased platelet concentration. These platelet-enhanced recirculation zones produced a diverse distribution of cells inside the aneurysm, for the different aspect ratios. A thin red blood CFL that was occupied by platelets was observed on the top of the wide-necked aneurysm, whereas a high-haematocrit region very close to the vessel wall was present in the narrow-necked case. The simulations revealed that non-trivial distributions of red blood cells and platelets are possible inside aneurysmal geometries, giving rise to several hypotheses on the formation of a thrombus, as well as to the wall weakening and the possible rupture of an aneurysm.
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