Evidence map›Paper›PMID 24427531›Full record

ArticleInterface focus2013

Navigating legal constraints in clinical data warehousing: a case study in personalized medicine.

Benjamin R Jefferys, Iheanyi Nwankwo, Elias Neri, David C W Chang, Lev Shamardin, Stefanie Hänold, Norbert Graf, Nikolaus Forgó, Peter Coveney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical Data Warehousing: A Scoping Review.Journal of the Society for Clinical Data Management · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin R JefferysCentre for Computational Science, Department of Chemistry , University College London , London WC1H 0AJ , UK.
Iheanyi NwankwoInstitut für Rechtsinformatik (IRI) , Leibniz Universität Hannover , Königsworther Platz 1, 30167 Hannover , Germany.
Elias NeriCustodix, Kortrijkseteenweg, 9830 Sint-Martens-Latem , Belgium.
David C W ChangCentre for Computational Science, Department of Chemistry , University College London , London WC1H 0AJ , UK.
Lev ShamardinCentre for Computational Science, Department of Chemistry , University College London , London WC1H 0AJ , UK.
Stefanie HänoldInstitut für Rechtsinformatik (IRI) , Leibniz Universität Hannover , Königsworther Platz 1, 30167 Hannover , Germany.
Norbert GrafSaarland University Hospital Faculty of Medicine , Campus Homburg Building no. 9, 66421 Homburg , Germany.
Nikolaus ForgóInstitut für Rechtsinformatik (IRI) , Leibniz Universität Hannover , Königsworther Platz 1, 30167 Hannover , Germany.
Peter CoveneyCentre for Computational Science, Department of Chemistry , University College London , London WC1H 0AJ , UK.

Funding

Medical Research Council MR/K006584/1
6 · The paper itself

Abstract

Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of clinical data is constrained by many legal and ethical considerations, owing to the sensitive nature of the data being stored. We describe an unconstrained clinical data warehousing architecture, some of the legal constraints that have led us to reconsider this architecture, and the legal and technical solutions to these constraints developed for the clinical data warehouse in the personalized medicine project p-medicine. We also propose some changes to the legal constraints that will further enable clinical research.

Indexed as

clinical data warehouselegal and ethical constraintspersonalized medicine

Identifiers

PMID24427531
PMCPMC3638485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.