ArticleInterface focus2013
Multiscale modelling of insulin secretion during an intravenous glucose tolerance test.
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Local Paracrine Actions of the Pancreatic α-Cell.Diabetes · 2020Review
- A Unifying Organ Model of Pancreatic Insulin Secretion.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysfunctional insulin secretion from pancreatic β-cells plays a major role in the development of diabetes. The intravenous glucose tolerance test (IVGTT) is a widely used clinical test to assess β-cell function. The analysis of IVGTT data is conveniently performed using mathematical models, which need to be fairly simple to enable parameter identifiability (minimal models), but should at the same time have sound biological foundation at the cellular level. Using mathematical analysis and model reduction, we show here that our recent mathematical model of insulin secretory granule dynamics in β-cells provides mechanistic underpinning for our minimal model of pancreatic insulin secretion during an IVGTT.
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Registered trials
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