ArticleInterface focus2013
Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation.
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Ten-year Follow-up Study of Patients with Persistent Atrial Fibrillation Treated by Combined Pulmonary Vein Isolation and Complex Fractionated Electrogram Ablation.Arrhythmia & electrophysiology review · 2025Article
- Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve.Scientific reports · 2022Article
- Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.International journal of molecular sciences · 2021Review
- Neural Tissue Degeneration in Rosenthal's Canal and Its Impact on Electrical Stimulation of the Auditory Nerve by Cochlear Implants: An Image-Based Modeling Study.International journal of molecular sciences · 2020Article
- Challenges Associated with Interpreting Mechanisms of AF.Arrhythmia & electrophysiology review · 2020Review
- Understanding the Beat-to-Beat Variations of P-Waves Morphologies in AF Patients During Sinus Rhythm: A Scoping Review of the Atrial Simulation Studies.Frontiers in physiology · 2019Article
- A technique for measuring anisotropy in atrial conduction to estimate conduction velocity and atrial fibre direction.Computers in biology and medicine · 2019Article
- Patient-specific simulations predict efficacy of ablation of interatrial connections for treatment of persistent atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2018Article
- Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics.PLoS computational biology · 2018Article
- Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography.Biophysical journal · 2018Article
- Structural heterogeneity of the rat pulmonary vein myocardium: consequences on intracellular calcium dynamics and arrhythmogenic potential.Scientific reports · 2018Article
- In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.PLoS computational biology · 2017Article
- Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.Pharmacology & therapeutics · 2016Review
- Optimization of catheter ablation of atrial fibrillation: insights gained from clinically-derived computer models.International journal of molecular sciences · 2015Review
- A mathematical model of the unidirectional block caused by the pulmonary veins for anatomically induced atrial reentry.Journal of biological physics · 2014Article
- Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014Article
- Article
- Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Mechanisms underlying the genesis of re-entrant substrate for the most common cardiac arrhythmia, atrial fibrillation (AF), are not well understood. In this study, we develop a multi-scale three-dimensional computational model that integrates cellular electrophysiology of the left atrium (LA) and pulmonary veins (PVs) with the respective tissue geometry and fibre orientation. The latter is reconstructed in unique detail from high-resolution (approx. 70 μm) contrast micro-computed tomography data. The model is used to explore the mechanisms of re-entry initiation and sustenance in the PV region, regarded as the primary source of high-frequency electrical activity in AF. Simulations of the three-dimensional model demonstrate that an initial break-down of normal electrical excitation wave-fronts can be caused by the electrical heterogeneity between the PVs and LA. High tissue anisotropy is then responsible for the slow conduction and generation of a re-entrant circuit near the PVs. Evidence of such circuits has been seen clinically in AF patients. Our computational study suggests that primarily the combination of electrical heterogeneity and conduction anisotropy between the PVs and LA tissues leads to the generation of a high-frequency (approx. 10 Hz) re-entrant source near the PV sleeves, thus providing new insights into the arrhythmogenic mechanisms of excitation waves underlying AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.