ArticleInterface focus2013
Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM).
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Modeling Realistic Geometries in Human Intrathoracic Airways.Diagnostics (Basel, Switzerland) · 2024Review
- Computational fluid dynamics of the airways after left-upper pulmonary lobectomy: A case study.International journal for numerical methods in biomedical engineering · 2021Article
- A porous circulation model of the human brain forInterface focus · 2021Article
- Structural and functional alterations of the tracheobronchial tree after left upper pulmonary lobectomy for lung cancer.Biomedical engineering online · 2019Article
- Personalized medicine for patients with COPD: where are we?International journal of chronic obstructive pulmonary disease · 2019Review
- Optimising mechanical ventilation through model-based methods and automation.Annual reviews in control · 2019Review
- Airflow in Tracheobronchial Tree of Subjects with Tracheal Bronchus Simulated Using CT Image Based Models and CFD Method.Journal of medical systems · 2018Article
- Coupled Immunological and Biomechanical Model of Emphysema Progression.Frontiers in physiology · 2018Article
- Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD.BioMed research international · 2018Article
- Substance deposition assessment in obstructed pulmonary system through numerical characterization of airflow and inhaled particles attributes.BMC medical informatics and decision making · 2017Article
- Transient Dynamics Simulation of Airflow in a CT-Scanned Human Airway Tree: More or Fewer Terminal Bronchi?Computational and mathematical methods in medicine · 2017Article
- Enabling Anyone to Translate Clinically Relevant Ideas to Therapies.Pharmaceutical research · 2017Article
- Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet.American journal of respiratory and critical care medicine · 2016Article
- In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches.The AAPS journal · 2015Review
- Article
- Destination Airway: Tracking Granulocytes in Asthma.EBioMedicine · 2014Article
- Synergy-COPD: a systems approach for understanding and managing chronic diseases.Journal of translational medicine · 2014Article
- Computational modeling of the obstructive lung diseases asthma and COPD.Journal of translational medicine · 2014Article
- Skin stem cell hypotheses and long term clone survival--explored using agent-based modelling.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
the respiratory system comprises several scales of biological complexitythe genes, cells and tissues that work in concert to generate resultant function. Malfunctions of the structure or function of components at any spatial scale can result in diseases, to the detriment of gas exchange, right heart function and patient quality of life. Vast amounts of data emerge from studies across each of the biological scales; however, the question remains: how can we integrate and interpret these data in a meaningful way? Respiratory disease presents a huge health and economic burden, with the diseases asthma and chronic obstructive pulmonary disease (COPD) affecting over 500 million people worldwide. Current therapies are inadequate owing to our incomplete understanding of the disease pathophysiology and our lack of recognition of the enormous disease heterogeneity: we need to characterize this heterogeneity on a patient-specific basis to advance healthcare. In an effort to achieve this goal, the AirPROM consortium (Airway disease Predicting Outcomes through patient-specific computational Modelling) brings together a multi-disciplinary team and a wealth of clinical data. Together we are developing an integrated multi-scale model of the airways in order to unravel the complex pathophysiological mechanisms occurring in the diseases asthma and COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.