ArticleIranian journal of pediatrics2013
Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children.
Article in Iranian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2021Pooled it
- Long-term antibiotics for preventing recurrent urinary tract infection in children.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for primary vesicoureteric reflux.The Cochrane database of systematic reviews · 2019Pooled it
- Probiotics for preventing urinary tract infection in people with neuropathic bladder.The Cochrane database of systematic reviews · 2017Pooled it
- Probiotics for preventing urinary tract infections in adults and children.The Cochrane database of systematic reviews · 2015Pooled it
- Probiotics in addition to antibiotics for the treatment of acute tonsillitis: a randomized, placebo-controlled study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Trial
- Efficacy of Probiotic Supplementation for Preventing Pediatric Urinary Tract Infections: A GRADE-Based Dose-Response Meta-Analysis.Health science reports · 2026Review
- UropathogenicAntibiotics (Basel, Switzerland) · 2026Review
- The role of probiotics in restoring and maintaining vaginal microbiome health: a review.Infection and immunity · 2026Review
- Lactobacillus strains in the prevention and disruption of antimicrobial-resistance in pathogenic microbial biofilms: a review of mechanisms and clinical perspective.Folia microbiologica · 2026Review
- Developing novel synbiotic low-fat yogurt using sour cherry pomace pectin-derived oligosaccharides:Journal of food science and technology · 2025Article
- Article
- Diagnostic and treatment patterns in urinary and genital tract infections: insights from a referral clinic in Beirut, Lebanon.World journal of urology · 2024Article
- Effective antimicrobial therapies of urinary tract infections among children in low- and middle-income countries: A systematic review.Pediatric investigation · 2023Review
- Non-antibiotic Approaches to Preventing Pediatric UTIs: a Role for D-Mannose, Cranberry, and Probiotics?Current urology reports · 2022Review
- Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children.Frontiers in pharmacology · 2022Review
- Perspectives from the Society for Pediatric Research: Probiotic use in urinary tract infections, atopic dermatitis, and antibiotic-associated diarrhea: an overview.Pediatric research · 2021Review
- Article
- Current status of long-term antibiotic prophylaxis for urinary tract infections in children: An antibiotic stewardship challenge.Kidney research and clinical practice · 2019Review
- Prevention of Renal Scarring in Acute Pyelonephritis by Probiotic Therapy: an Experimental Study.Probiotics and antimicrobial proteins · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe examined the preventive effect of probiotic and antibiotics versus antibiotics alone, in children with recurrent urinary tract infections (RUTI) in a preliminary randomized clinical trial.
methodsBetween March 2007 and April 2011, children with the history of RUTI and unilateral vesicoureteral reflux (VUR) were randomly assigned to receive concomitant probiotic and antibiotics (Lactobacillus acidophilus and bifidobacterium lactis, 10(7)/ml, as 0.25 ml/kg three times a day regimen in addition to Nitrofurantoin, 1mg/kg daily (group I). In group II, all children received conventional prophylactic antibiotics alone (Nitrofurantoin, 1 mg/kg daily). Randomization was performed via using the random numerals table in a 1:1 manner with stratification by sex, age and grade of reflux. The urine examinations were done monthly and the incidence of UTI was evaluated in these two groups.
findingsForty-one children (age: 8.3±3.1 years) in group I and 44 children (age: 8.0±3.0 years) in group II were compared. During the course of three years, 39% in group I and 50% of participants in group II experienced RUTIs (P=0.4). Incidences of UTI - febrile and afebrile - reduced in both groups without any significant differences after two years of prophylaxis. Also, incidence of afebrile UTIs did not significantly differ (0.51±1.30 and 0.81±1.41 respectively, P =0.3); however, the incidence of febrile UTIs in particular were lower in group I (0.00±0.00 versus 0.13±0.40, P =0.03) in the last year.
conclusionThe consumption of probiotic and antibiotics in children with RUTI is safe and more effective in reducing the incidence of febrile UTI in comparison to prophylactic antibiotics alone.
Indexed as
Identifiers
24427497PMC3883373W2101290218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.