Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.

Ruifeng Guo, Xianfu Wang, Jie Chen, Ellizabeth Gillies, Kar-Ming Fung, Shibo Li, Lewis A Hassell

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In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ruifeng GuoDepartment of Pathology, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Xianfu WangDepartment of Pediatrics, Genetics Laboratory, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Jie ChenDepartment of Pathology, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Ellizabeth GilliesDepartment of Pathology, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Kar-Ming FungDepartment of Pathology, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Shibo LiDepartment of Pediatrics, Genetics Laboratory, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

Lewis A HassellDepartment of Pathology, University of Oklahoma Health Sciences Center Oklahoma city, OK, USA.

University of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported three cases of metastatic melanoma that does not express S100, HMB45, Melan A and Tyrosinase. A concurrent cutaneous scalp primary melanoma was identified later in one of the cases, which showed strong expression of these markers. The difference in immunophenotype between the primary melanoma and its metastasis in the parotid gland in this case raised the question of the biological significance of the expression of these markers and metastatic potential. To address this question, we utilized microarray comparative genomic hybridization (aCGH) to compare the cytogenetic features between the primary and metastatic melanoma. We observed chromosomal gains including 6p, entire chromosome 7, and 8q11.1-q24.3 in both primary and metastatic tumors. However, the metastatic lesion showed unique additional copy of chromosomal 7q, and loss of chromosome 9p24.3-q13 and chromosome 4, which included Melan A encoding gene region in 9p24.1. The above findings suggest the unique cytogenetic changes in the parotid lesion are most likely related to the metastatic behavior, as well as responsible for loss of multiple melanocytic marker expression in the metastatic melanoma for this case.

Indexed as

Biomarkers, TumorComparative Genomic Hybridizationgp100 Melanoma AntigenHumansMART-1 AntigenMelanomaMelanoma-Specific AntigensMonophenol MonooxygenaseNeoplasm MetastasisS100 ProteinsSkin NeoplasmsBiomarkers, Tumorgp100 Melanoma AntigenMART-1 AntigenMelanoma-Specific AntigensMLANA protein, humanMonophenol MonooxygenasePMEL protein, humanS100 Proteinscomparative genomic hybridizationcytogeneticsMelanomametastasis

Identifiers

PMID24427375

PMCPMC3885509

OpenAlexW854055701

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.