Evidence map›Paper›PMID 24427365›Full record

ArticleInternational journal of clinical and experimental pathology2014

A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma.

Kei-Ji Sugimoto, Asami Shimada, Mutsumi Wakabayashi, Hidenori Imai, Yasunobu Sekiguchi, Noriko Nakamura, Tomohiro Sawada, Yasunori Ota, Kengo Takeuchi, Yoshinori Ito and 3 more

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PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Kei-Ji SugimotoDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Asami ShimadaDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Mutsumi WakabayashiDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Hidenori ImaiDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Yasunobu SekiguchiDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Noriko NakamuraDepartment of Clinical Laboratory, Juntendo University Urayasu Hospital Urayasu, Japan.
Tomohiro SawadaDepartment of Clinical Laboratory, Juntendo University Urayasu Hospital Urayasu, Japan.
Yasunori OtaDepartment of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo Japan.
Kengo TakeuchiPathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research Tokyo, Japan.
Yoshinori ItoDepartment of Pediatrics, Nagoya University Graduate School of Medicine Nagoya, Japan.
Hiroshi KimuraDepartment of Virology, Nagoya University Graduate School of Medicine Nagoya, Japan.
Norio KomatsuDepartment of Hematology, Juntendo University School of Medicine Tokyo, Japan.
Masaaki NoguchiDepartment of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
Nagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The patient was a 52-year old woman with a history of mosquito-bite hypersensitivity since childhood. In July 2011, she developed pyrexia, headaches, and nausea, and Epstein-Barr virus (EBV)-positive aggressive natural killer leukemia (ANKL) was diagnosed on the basis of both a peripheral blood and bone marrow examination. An inguinal lymph node biopsy, on the other hand, revealed EBV-positive cytotoxic T-cell lymphoma plus the presence of a small number of EBV-positive ANKL cells, and a diagnosis of EBV-positive composite lymphoma was made. Both the cytotoxic T-cell lymphoma and ANKL exhibited EBV terminal repeat (Southern blot analysis) monoclonal patterns, and they were almost the same size, approximately 9.0 kb. If it was the identical EBV clone, it is possible that EBV infected progenitor cells common to both NK cells and T cells, that the progenitor cells then differentiated into NK cells and T cells, a chronic active Epstein-Barr virus infection developed, and neoplastic transformation occurred. If it was not the identical EBV clone, fairly similar EBVs must have infected NK cells and T cells separately, and they then underwent neoplastic transformation. Because the mechanism by which EBV infects NK cells or T cells is still unknown, we concluded that this case is also important from the standpoint of elucidating it. We are currently in the process of conducting gene analyses to determine whether the fairly similar EBVs that infected the ANKL and cytotoxic T-cell lymphoma are the identical clone.

Indexed as

Composite LymphomaEpstein-Barr Virus InfectionsFemaleFlow CytometryHumansHypersensitivityInsect Bites and StingsLeukemia, Large Granular LymphocyticLymphoma, T-CellMiddle AgedAggressive NK leukemiacomposite lymphomacytotoxic T-cell lymphomaEpstein-Barr viruslarge granular lymphocytes

Identifiers

PMID24427365
PMCPMC3885499
OpenAlexW1693738209

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.