ArticleInternational journal of clinical and experimental pathology2014
Mouse endometrial stromal cells and progesterone inhibit the activation and regulate the differentiation and antibody secretion of mouse B cells.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Role of sex and gender in autoimmune thyroid diseases: mechanisms and knowledge gaps.Reviews in endocrine & metabolic disorders · 2026Review
- Sex Steroid Hormone Regulation of T-Cell Function and Antitumor Immunity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Review
- B Cell Tolerance and Obstetric Antiphospholipid Syndrome.Clinical reviews in allergy & immunology · 2025Review
- Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications.Nature reviews. Cancer · 2024Article
- Review
- Hormones and B-cell development in health and autoimmunity.Frontiers in immunology · 2024Review
- B cells: roles in physiology and pathology of pregnancy.Frontiers in immunology · 2024Review
- Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis.Journal of neuroinflammation · 2023Article
- Sex-the most underappreciated variable in research: insights from helminth-infected hosts.Veterinary research · 2022Review
- A Comprehensive Investigation into the Distribution of Circulating B Cell Subsets in the Third Trimester of Pregnancy.Journal of clinical medicine · 2022Article
- Antibody Response to Pertussis Vaccination in Pregnant and Non-Pregnant Women-The Role of Sex Hormones.Vaccines · 2021Article
- Progesterone promotes immunomodulation and tumor development in the murine mammary gland.Journal for immunotherapy of cancer · 2021Article
- Hormone-Related Cancer and Autoimmune Diseases: A Complex Interplay to be Discovered.Frontiers in genetics · 2021Review
- Article
- Progesterone-Related Immune Modulation of Pregnancy and Labor.Frontiers in endocrinology · 2019Review
- Linking autoimmunity to the origin of the adaptive immune system.Evolution, medicine, and public health · 2018Article
- Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy.Frontiers in immunology · 2018Review
- Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites.Mucosal immunology · 2017Review
- A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice.Frontiers in immunology · 2017Article
- Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study.BMC pregnancy and childbirth · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation mechanism for the B cells in the female reproductive tract (FRT) is unclear now. The aim of this study was to analysis the effect of progesterone and mouse endometrium stromal cells (ESCs) on B cells and explore it roles in modulating B cells-mediated immune responses. We primary isolated mouse ESCs from endometrium of BALB/c mice and B cells from spleen cells of BALB/c mice, and then constructed these two kind of cells co-culture system, and treated with or without progesterone. We found that both treatment with progesterone and co-culture with ESCs reduced the expression of co-stimulatory molecules CD80 and CD86 on mouse B cells from spleen cells. In addition, the expression of CD138 (syndecan-1) on B cells was increased after co-culture with ESCs, however, progesterone could partly reduce this effect. Unlike progesterone, ESCs alone promoted the proliferation and stimulated the secretion level of antibodies IgG and IgA of B cells. Our current results progesterone and ESCs could inhibit the activation of B cells through deceasing CD80 and CD86 expression, regulated the differentiation status of B cells by up-regulating the expression of CD138 together, and might further inhibit the antigen presentation function of B cells, which is beneficial to the establishment of fertilization and pregnancy. In addition, ESCs also promoted the proliferation and antibody secretion, which might participate in the resisting infections during non pregnancy and pregnancy.
Indexed as
Identifiers
24427332PMC3885466W2297921530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.