SynthesisPloS one2014
Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy of neurofeedback in the treatment of Dyslexia: a systematic review.Annals of dyslexia · 2026Pooled it
- Examination of common and unique brain regions for atypical reading and math: a meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Pooled it
- Reading intervention and neuroplasticity: A systematic review and meta-analysis of brain changes associated with reading intervention.Neuroscience and biobehavioral reviews · 2022Pooled it
- Pooled it
- Where arithmetic and phonology meet: The meta-analytic convergence of arithmetic and phonological processing in the brain.Developmental cognitive neuroscience · 2018Pooled it
- From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention.NeuroImage. Clinical · 2017Trial
- Developmental Reading-Network Reorganization in Developmental Dyslexia: A Neuroplasticity Framework.Brain sciences · 2026Review
- Combined accelerated theta burst stimulation and reading instruction for the treatment of persistent developmental dyslexia: methodology and preliminary findings.Frontiers in human neuroscience · 2026Article
- The balance between stability and plasticity of the visual word form area in dyslexia.Nature communications · 2025Article
- Brain Changes Following Two Reading Interventions in Chinese Children With Reading Disability.Developmental science · 2025Article
- Article
- Development of the arcuate fasciculus is linked to learning gains in reading.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Data-driven exploratory method investigation on the effect of dyslexia education at brain connectivity in Turkish children: a preliminary study.Brain structure & function · 2024Article
- Sex Differences in White Matter Diffusivity in Children with Developmental Dyslexia.Children (Basel, Switzerland) · 2024Article
- The reading-attention relationship: Variations in working memory network activity during single word decoding in children with and without dyslexia.Neuropsychologia · 2024Article
- Reaching Students with Reading Disabilities During the Summer.Policy insights from the behavioral and brain sciences · 2024Article
- Will you read how I will read? Naturalistic fMRI predictors of emergent reading.Neuropsychologia · 2024Article
- White matter microstructural plasticity associated with educational intervention in reading disability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Characterization of Cortical and Subcortical Structural Brain Asymmetry in Adults with and without Dyslexia.Brain sciences · 2023Article
- The Brain's Control Networks in Reading: Insights From Cross-Task Studies of Youth.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A growing number of studies examine instructional training and brain activity. The purpose of this paper is to review the literature regarding neuroimaging of reading intervention, with a particular focus on reading difficulties (RD). To locate relevant studies, searches of peer-reviewed literature were conducted using electronic databases to search for studies from the imaging modalities of fMRI and MEG (including MSI) that explored reading intervention. Of the 96 identified studies, 22 met the inclusion criteria for descriptive analysis. A subset of these (8 fMRI experiments with post-intervention data) was subjected to activation likelihood estimate (ALE) meta-analysis to investigate differences in functional activation following reading intervention. Findings from the literature review suggest differences in functional activation of numerous brain regions associated with reading intervention, including bilateral inferior frontal, superior temporal, middle temporal, middle frontal, superior frontal, and postcentral gyri, as well as bilateral occipital cortex, inferior parietal lobules, thalami, and insulae. Findings from the meta-analysis indicate change in functional activation following reading intervention in the left thalamus, right insula/inferior frontal, left inferior frontal, right posterior cingulate, and left middle occipital gyri. Though these findings should be interpreted with caution due to the small number of studies and the disparate methodologies used, this paper is an effort to synthesize across studies and to guide future exploration of neuroimaging and reading intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.