ArticleNucleic acids research1987
Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.
Article in Nucleic acids research, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 101 citations in OpenAlex.
- Use of 4-Nitroquinoline 1-Oxide (4NQO) in Dysplastic and Malignant Induction: In Vitro and In Vivo Studies.Biomedicines · 2025Article
- The transcriptomic revolution and radiation biology.International journal of radiation biology · 2022Article
- Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma.Frontiers in oncology · 2020Review
- Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.The EMBO journal · 2010Article
- The 3' processing factor CstF functions in the DNA repair response.Nucleic acids research · 2008Article
- Functional expression of recombinant human stefin A in mammalian and bacterial cells.Protein expression and purification · 2007Article
- DNA damage enhances melanogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Characterization by spectroscopic, kinetic and equilibrium methods of the interaction between recombinant human cystatin A (stefin A) and cysteine proteinases.The Biochemical journal · 1995Article
- A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.Nucleic acids research · 1991Article
- Rapid and preferential activation of the c-jun gene during the mammalian UV response.Molecular and cellular biology · 1991Article
- A PstI DNA polymorphism in the human stefin A gene (STF 1).Nucleic acids research · 1991Article
- Ultraviolet B radiation induction of ornithine decarboxylase gene expression in mouse epidermis.The Biochemical journal · 1990Article
- Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.Nucleic acids research · 1990Article
- DNA damage induction of ribonucleotide reductase.Molecular and cellular biology · 1989Article
- DNA damage-inducible transcripts in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.Molecular and cellular biology · 1988Article
- Novel protein in human epidermal keratinocytes: regulation of expression during differentiation.Molecular and cellular biology · 1988Article
- Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an approach to study effects of UV light on gene expression in human epidermal keratinocytes, a cDNA library was constructed from poly(A)RNA isolated after UV irradiation from cultured keratinocytes. The cDNA library was differentially screened with labelled cDNA probes synthesized on poly(A)RNA isolated from UV irradiated or nonirradiated keratinocytes. Forty clones were selected and subjected to further analysis, 31 of them are described in this report. Whereas total mRNA synthesis is reduced after UV irradiation or treatment with 4-NQO Northern blot analysis revealed that there is an at least relative increase in the level of mRNAs corresponding to the majority of the isolated cDNA clones. Among these 15 were identified as corresponding to mRNAs for 50K and 56K keratins and for 50K- and 46K-related keratin. In addition, clones were found corresponding to the proteinase inhibitor cystatin A and to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Treatment of keratinocytes with the tumor promoter TPA had no effect on the mRNA level for most of the clones except those corresponding to keratins. Our results indicate that in keratinocytes UV irradiation leads to a relative increase in the level of some mRNAs.
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