ReviewFrontiers in integrative neuroscience2014
Anterior Cingulate epilepsy: mechanisms and modulation.
Review in Frontiers in integrative neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Interpretable Multiscale Directed Temporal Graph Learning for MEG-Based Identification and Lateralization of Temporal Lobe Epilepsy.Sensors (Basel, Switzerland) · 2026Article
- Old Lesions and New Targets: sEEG-Identified Onsets in Traditionally Inoperable Epilepsy Lesions and Associated Surgical Outcomes.Pediatric neurosurgery · 2026Review
- Research progress of connexins in epileptogensis.Acta epileptologica · 2025Review
- Increased GluK1 Subunit Receptors in Corticostriatal Projection from the Anterior Cingulate Cortex Contributed to Seizure-Like Activities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Case report: First experience with stimulating anterior thalamic nuclei in pharmacoresistant epilepsy in Kazakhstan.Frontiers in human neuroscience · 2024Article
- Propofol mitigates brain injury and oxidative stress, and enhances GABAA receptor α1 subunit expression in a rat model of lithium chloride-pilocarpine induced status epilepticus.Turkish journal of medical sciences · 2023Article
- Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.Cell reports · 2022Article
- Distinct effects of the basal ganglia and cerebellum on the thalamocortical pathway in idiopathic generalized epilepsy.Human brain mapping · 2021Article
- C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning.Acta cirurgica brasileira · 2020Article
- Spectral entropy indicates electrophysiological and hemodynamic changes in drug-resistant epilepsy - A multimodal MREG study.NeuroImage. Clinical · 2019Article
- Dendrite growth and the effect of ectopic Rheb expression on cortical neurons.Neuroscience letters · 2018Article
- Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex.Scientific reports · 2018Article
- Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice.Molecular brain · 2017Article
- Spiders, ladybugs and bees: A case of unusual sensations in a child with cingulate epilepsy.Epilepsy & behavior case reports · 2017Article
- Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.Scientific reports · 2016Article
- Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient.Neuropsychiatric disease and treatment · 2016Article
- Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making.Psychopharmacology · 2015Article
- Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.BMC neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a common neurological disorder, about 1% population worldwide suffered from this disease. In 1989, the International League Against Epilepsy (ILAE) classified anterior cingulate epilepsy as a form of frontal lobe epilepsy (FLE). FLE is the second most common type of epilepsy. Previous clinical studies showed that FLE account an important cause in refractory epilepsy, therefore to find alternative approach to modulate FLE is very important. Basic research using animal models and brain slice have revealed some insights on the epileptogenesis and modulation of seizure in anterior cingulate cortex (ACC). Interneurons play an important role in the synchronization of cingulate epilepsy. Research has shown that the epileptogenesis of seizure originated from mesial frontal lobe might be caused by a selective increase in nicotine-evoked γ-aminobutyric acid (GABA) inhibition, because the application of the GABAA receptor antagonist picrotoxin inhibited epileptic discharges. Gap junctions are also involved in the regulation of cingulate epilepsy. Previous studies have shown that the application of gap junction blockers could attenuate ACC seizures, while gap junction opener could enhance them in an in vitro preparation. μ-Opioid receptors have been shown to be involved in the epileptic synchronization mechanism in ACC seizures in a brain slice preparation. Application of the μ-opioid agonist DAMGO significantly abolished the ictal discharges in a 4-aminopyridine induced electrographic seizure model in ACC. Basic research has also found that thalamic modulation has an inhibitory effect on ACC seizures. Studies have shown that the medial thalamus may be a target for deep brain stimulation to cure ACC seizures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.