ArticleHand (New York, N.Y.)2013
Functional outcome of collagenase injections compared with fasciectomy in treatment of Dupuytren's contracture.
Article in Hand (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Collagenase clostridium histolyticum injection versus limited fasciectomy for the treatment of Dupuytren's disease: a systematic review and meta-analysis of comparative studies.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Treatment of Dupuytren's Contracture With Collagenase: A Systematic Review.Hand (New York, N.Y.) · 2022Pooled it
- Systematic review of non-surgical treatments for early dupuytren's disease.BMC musculoskeletal disorders · 2016Pooled it
- Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review.British medical bulletin · 2016Pooled it
- Dupuytren Disease Surgical Treatment: A Randomized Clinical Trial Comparing Partial Fasciectomy by Bruner Approach Versus Zetaplasty.Hand (New York, N.Y.) · 2024Trial
- Trial
- Flexor Tendon Rupture Following CollagenaseJournal of personalized medicine · 2026Review
- Therapy for Dupuytren's Disease (II): Collagenase Therapy vs. Limited Fasciectomy-A Long-Term Comparative Study.Life (Basel, Switzerland) · 2025Article
- Therapy for Dupuytren's Disease: Collagenase Therapy-A Long-Term Follow-Up Study.Life (Basel, Switzerland) · 2024Article
- Review
- Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection.Hand (New York, N.Y.) · 2023Article
- Short-term efficacy and adverse effects of collagenase clostridium histolyticum injections, percutaneous needle fasciotomy and limited fasciectomy in the treatment of Dupuytren's contracture: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2022Article
- Dupuytren Disease: A Retrospective Cohort Study Comparing Collagenase Injection and Percutaneous Needle Fasciotomy.Plastic and reconstructive surgery. Global open · 2022Article
- Long-Term Outcomes of Collagenase Clostridium Histolyticum Injection for Palmar Dupuytren's Deformity Correction.Cureus · 2021Article
- Cost-effectiveness of Recurrent Dupuytren Contracture Treatment.JAMA network open · 2020Article
- Dupuytren Disease Management Trends: A Survey of Hand Surgeons.Hand (New York, N.Y.) · 2020Article
- Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture: 2-Year Follow-up.Clinics in orthopedic surgery · 2019Article
- Dupuytren's disease: where do we stand?EFORT open reviews · 2019Review
- From Bench to Bedside: Stiffness Begone! (in a Needle).Clinical orthopaedics and related research · 2018Article
- Clinical outcomes following collagenase injections compared to fasciectomy in the treatment of Dupuytren's contracture.Hand (New York, N.Y.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was designed to provide comparative information on the safety and efficacy of injection with collagenase clostridium histolyticum (CCH) and fasciectomy for patients with Dupuytren's contracture (DC).
methodsA single-center, retrospective, observational, longitudinal chart review was conducted of 25 patients treated with CCH injections and 21 patients undergoing fasciectomy. Patients were assessed at 1 week, monthly for 3 months and then yearly for a minimum of 2 years after treatment for changes in contracture and range of motion, time to return to work/normal activities, patient satisfaction, and Disabilities of Arm, Shoulder and Hand (DASH) score.
resultsPost-procedure follow-up averaged 32 months for the injection group compared with 39 months for fasciectomy group. For the CCH group, the mean postinjection contracture was 3.6° for the metacarpophalangeal and 17.5° for the proximal interphalangeal joints compared with 3.7° and 8.1° in the fasciectomy group, respectively. Patients treated with injections returned to normal activities after a mean of 1.9 days compared with 37.4 days for fasciectomy patients (p < 0.0001). DASH scores for 13 CCH and 15 fasciectomy patients were obtained. The mean DASH score was significantly lower in the injection group in the first 3 months (p < 0.01). At the 2-year follow-up visit, patients were satisfied with their outcomes following either treatment (92 % and 96 % of CCH and fasciectomy patients, respectively).
conclusionCCH injections are safe and effective and may be a viable alternative to fasciectomy for treating DC. It also allows earlier return to work and daily activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.