SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014
The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04399200 (Sleep Apnea Syndrome and Incidence of Major Adverse Cardiac and Cerebrovascular Events), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Apnea Syndrome and Incidence of Major Adverse Cardiac and Cerebrovascular Events (MACCEs) After a First Stroke
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Post-stroke sleep disturbance and recurrent cardiovascular and cerebrovascular events: A systematic review and meta-analysis.Sleep medicine · 2023Pooled it
- Positive airway pressure therapy for post-stroke sleep disordered breathing: a systematic review, meta-analysis and meta-regression.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Traditional Chinese Medicine for Post-stroke Sleep Disorders: The Evidence Mapping of Clinical Studies.Frontiers in psychiatry · 2022Pooled it
- Sleep-disordered breathing and the risk of cognitive decline: a meta-analysis of 19,940 participants.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Pooled it
- The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum.PloS one · 2019Trial
- Trial
- Impacts of obstructive sleep apnea on collateral circulation in stroke patients with proximal middle cerebral artery stenosis or occlusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Sleep Apnea and Stroke: A Narrative Review.Chest · 2024Review
- Sleep-Disordered Breathing and Prognosis after Ischemic Stroke: It Is Not Apnea-Hypopnea Index That Matters.Diagnostics (Basel, Switzerland) · 2023Article
- Positive airway pressure treatment for sleep-disordered breathing is rare during the first year after stroke: The BASIC project.Sleep medicine · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Sleep-Disordered Breathing in Acute Stroke: A Single-Center, Prospective, Longitudinal Study.Journal of clinical medicine · 2023Article
- Breathing Exercises for Improving Cognitive Function in Patients with Stroke.Journal of clinical medicine · 2022Review
- Recent advances in the management of transient ischemic attacks.Faculty reviews · 2022Review
- Respiratory disorders during sleep in patients with acute ischemic stroke.Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
- Sleep Disorders in Stroke: An Update on Management.Aging and disease · 2021Review
- Impairment of cognition and sleep after acute ischaemic stroke or transient ischaemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicentre prospective registry.Stroke and vascular neurology · 2021Article
- Application of Wireless Dynamic Sleep Monitor in Acupuncture Treatment of Insomnia after Ischemic Stroke: A Retrospective Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Sleep problems worsen health-related quality of life and participation during the first 12 months of stroke rehabilitation.Clinical rehabilitation · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThe primary objective was to systematically review the literature on how sleep disordered breathing (SDB) affects recurrence and death among stroke or transient ischemic attack (TIA) patients. A secondary objective was to evaluate how treatment of SDB with continuous positive airway pressure (CPAP) affects the risk of recurrence and death in these patients.
methodsAdults (18+) with a stroke or TIA diagnosis were eligible for inclusion. Case groups consisted of patients with a sleep disorder. The outcomes of interest were all-cause mortality, recurrent vascular events, and case fatality.
resultsTen articles covering 1,203 stroke and TIA patients were included in the review. The results generally support a dose-response relationship between severity of SDB and risk of recurrent events and all-cause mortality in stroke and TIA patients. Three small-scale articles with substantial risk of bias evaluated the effects of CPAP therapy, and the results are inconclusive. Data on case fatality is too sparse to be conclusive.
conclusionsExisting studies provide sufficient data to establish obstructive SDB as a negative predictor of all-cause mortality and recurrent vascular events following stroke or TIA. The ability of CPAP treatment to lower the risk of serious adverse outcomes after stroke remains controversial because of substantial risk of bias identified in most of the eligible studies addressing this relation. Additional studies are needed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.