Evidence map›Paper›PMID 24426245›Full record

ArticleIndian journal of clinical biochemistry : IJCB2013

Study of toxicity effect of pegylated nanoliposomal artemisinin on breast cancer cell line.

Neda Dadgar, Seyed Ebrahim Alavi, Maedeh Koohi Moftakhari Esfahani, Azim Akbarzadeh

Abstract read
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Antitumor Research on Artemisinin and Its Bioactive Derivatives.Natural products and bioprospecting · 2018
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Neda DadgarDepartment of Agricultural Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Seyed Ebrahim AlaviDepartment of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran ; Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Maedeh Koohi Moftakhari EsfahaniDepartment of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran ; Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Azim AkbarzadehDepartment of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano carriers have greatly revolutionized the treatment of most diseases recently. One of these nano carriers, liposomes, has got particular significance. On the other hand, Artemisinin which is used as an effective anticancer drug has some side effects. To reduce such side effects, liposomes can be employed. In order to prepare pegylated nanoliposomal artemisinin, particular proportions of phosphatidylcholine, polyethylene glycol 2000 and artemisinin were combined. As a result, the mean diameter of nano liposomes is 455 nm. Besides, the encapsulation efficiency and the drug release from pegylated nanoliposomes for pegylated nanoliposomal artemisinin are respectively 91.62 ± 3.5 and 5.17 %. The results also show that IC50 of the produced formulation is less than that of the standard drug. This study reveals that the amount of artemisinin cytotoxicity compared to standard drug is increased by pegylated nanoliposomal formulation.

Indexed as

ArtemisininBreast cancerNanoliposomePegylation

Identifiers

PMID24426245
PMCPMC3783905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.