Evidence map›Paper›PMID 24426193›Full record

ArticleJournal of clinical biochemistry and nutrition2014

The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial.

Kazuhiro Shimizu, Hironori Sato, Yoko Suga, Satoko Yamahira, Masamichi Toba, Koji Hamuro, Keiji Kakumoto, Noriyuki Kohda, Takao Akama, Ichiro Kono and 1 more

Abstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Effects ofJournal of Korean medical science · 2020
    Trial
  2. Trial
  3. Review
  4. Effect of Continuous Intake ofLife (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazuhiro ShimizuSports Research & Development Core, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Hironori SatoResearch & Development Department, Tsukuba Wellness Research Co., Ltd., D6 Block 8 Kenkyu-gakuen, Tsukuba, Ibaraki 305-0817, Japan.
Yoko SugaResearch & Development Department, Tsukuba Wellness Research Co., Ltd., D6 Block 8 Kenkyu-gakuen, Tsukuba, Ibaraki 305-0817, Japan.
Satoko YamahiraOtsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
Masamichi TobaOtsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
Koji HamuroOtsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
Keiji KakumotoInformation Management Office, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Co., Ltd., 463-10 Kawauchi-cho, Tokushima 771-0130, Japan.
Noriyuki KohdaOtsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
Takao AkamaFaculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.
Ichiro KonoGraduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Shinya KunoGraduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.

Indexed as

elderlyLactobacillus pentosuslow physical fitnessmucosal immunitysalivary SIgA

Identifiers

PMID24426193
PMCPMC3882487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.