ArticleJournal of clinical biochemistry and nutrition2014
Mitochondrial reactive oxygen species accelerate gastric cancer cell invasion.
Article in Journal of clinical biochemistry and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Intraperitoneal blue LED irradiation as a potential approach to suppress gastric cancer peritoneal dissemination in a murine model.Scientific reports · 2026Article
- Heme-porphyrin metabolism in photodynamic therapy associated with reactive oxygen species.Journal of clinical biochemistry and nutrition · 2026Article
- Diet, Gastric Microbiota, and Metabolites in Gastric Tumorigenesis.Research (Washington, D.C.) · 2025Review
- A Mechanism for Apoptotic Effects of a Planar Catechin Analog on Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Mitochondria: a new intervention target for tumor invasion and metastasis.Molecular medicine (Cambridge, Mass.) · 2024Review
- Reactive oxygen species induced by indomethacin enhance accumulation of heme carrier protein 1 and hematoporphyrin accumulationJournal of clinical biochemistry and nutrition · 2024Article
- Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog.ACS medicinal chemistry letters · 2024Article
- Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer.Antioxidants (Basel, Switzerland) · 2023Article
- Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy.Pharmaceutics · 2022Review
- Acetic acid enhances the effect of photodynamic therapy in gastric cancer cells via the production of reactive oxygen species.Journal of clinical biochemistry and nutrition · 2022Article
- Near-Infrared Light Irradiation of Porphyrin-Modified Gold Nanoparticles Promotes Cancer-Cell-Specific Cytotoxicity.Molecules (Basel, Switzerland) · 2022Article
- Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms.Molecules (Basel, Switzerland) · 2022Review
- Porphylipoprotein Accumulation and Porphylipoprotein Photodynamic Therapy Effects Involving Cancer Cell-Specific Cytotoxicity.International journal of molecular sciences · 2021Article
- Elevated Production of Mitochondrial Reactive Oxygen Species via Hyperthermia Enhanced Cytotoxic Effect of Doxorubicin in Human Breast Cancer Cell Lines MDA-MB-453 and MCF-7.International journal of molecular sciences · 2020Article
- 5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells.Journal of clinical biochemistry and nutrition · 2019Article
- Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation.Scientific reports · 2019Article
- Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment.Frontiers in oncology · 2019Article
- Acetic acid is an oxidative stressor in gastric cancer cells.Journal of clinical biochemistry and nutrition · 2018Article
- Monascus purpureus induced apoptosis on gastric cancer cell by scavenging mitochondrial reactive oxygen species.Journal of clinical biochemistry and nutrition · 2017Article
- Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell.Journal of clinical biochemistry and nutrition · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor invasion is the most important factor to decide patient's prognosis. The relation between reactive oxygen species and tumor invasion is mainly reported that nicotinamide adenine dinucleotide phosphate oxidase in the cell membrane is a reactive oxygen species producer for formulating an invadopodia. On the other hand, mitochondrion was known as one of the most important reactive oxygen species-producer in the cell via an energy transfer system. However, the relation between mitochondrial reactive oxygen species and the tumor invasion was not well clarified. In this study, we evaluated the relation between mitochondrial reactive oxygen species and tumor invasion using a normal gastric mucosal cell-line (RGM-1) and a cancerous mutant RGM-1 cell-line (RGK-1). Manganese superoxide dismutase-expressing RGK-1 cell-lines were used for a scavenging mitochondrial reactive oxygen species. The cells have been evaluated their movement ability as follows; cellular ruffling frequencies, wound healing assay to evaluate horizontal cellular migration, and invasion assay using matrigel to analyze vertical cellular migration. All cellular movement abilities were inhibited by scavenging mitochondrial reactive oxygen species with manganese superoxide dismutase. Therefore mitochondrial reactive oxygen species was one of factors enhancing the tumor invasion in gastric cancer.
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