ArticleMolecular and cellular biochemistry1987
Further characterization of an MSP-1-derived transcription particle (transcripton) using monoclonal and polyclonal antibodies.
Article in Molecular and cellular biochemistry, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
- ATP as an alternative inhibitor of bacterial and endogenous nucleases and its effect on native chromatin compaction.Molecular and cellular biochemistry · 1987Article
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1 author at 1 institution in 1 country.
Funding
Abstract
A native transcription particle (transcripton) derived from Novikoff nucleoli by digestion with MSP-1 was isolated and characterized. Various monoclonal and polyclonal antibodies were used to determine their subsequent effect upon the Native transcription particle (NTP) transcription assay. The NTP was enriched in RNA polymerase 1 and some/all of its factors, including a 145 kD protein, a 345 kD protein, and topoisomerase 1 (110 kD). Using Western analysis monoclonal antibody made against the transcripton recognized a 55 kD protein, which immunolocalized to nucleolar and nuclear membrane structures. This antibody caused transcriptional inhibition of the transcripton in subsequent assays as did the antibody to the 345 kD protein. The monoclonal antibody against the 145 kD protein had no effect on transcription. When antibody to topoisomerase 1 was included in the assay, enhancement of transcription was observed.
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