ArticleThe Journal of biological chemistry2014
Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Optimization of neuron-specific interfering peptides targeting GABAFrontiers in pharmacology · 2025Article
- Action of GABAThe journal of physiological sciences : JPS · 2024Article
- Role of Rab10 in cocaine-induced behavioral effects is associated with GABAB receptor membrane expression in the nucleus accumbens.Frontiers in pharmacology · 2024Article
- Targeting the interaction of GABABrain pathology (Zurich, Switzerland) · 2023Article
- GABACurrent topics in behavioral neurosciences · 2022Review
- Protein phosphatase 2A regulation of GABAFrontiers in molecular neuroscience · 2022Article
- Targeting the Interaction of GABAFrontiers in pharmacology · 2022Article
- Crosstalk Between GABAergic Neurotransmission and Inflammatory Cascades in the Post-ischemic Brain: Relevance for Stroke Recovery.Frontiers in cellular neuroscience · 2022Review
- Sustained Baclofen-Induced Activation of GABAFrontiers in molecular neuroscience · 2021Article
- CaMolecular neurobiology · 2019Article
- Neuroadaptations of presynaptic and postsynaptic GABABritish journal of pharmacology · 2017Article
- Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.The Journal of biological chemistry · 2016Article
- Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation.Cell reports · 2016Article
- NMDA Receptors Mediate Stimulus-Timing-Dependent Plasticity and Neural Synchrony in the Dorsal Cochlear Nucleus.Frontiers in neural circuits · 2015Article
- Cross-talk and regulation between glutamate and GABAB receptors.Frontiers in cellular neuroscience · 2015Review
- Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female rats.Endocrinology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Inhibitory GABAB receptors (GABABRs) can down-regulate most excitatory synapses in the CNS by reducing postsynaptic excitability. Functional GABABRs are heterodimers of GABAB1 and GABAB2 subunits and here we show that the trafficking and surface expression of GABABRs is differentially regulated by synaptic or pathophysiological activation of NMDA receptors (NMDARs). Activation of synaptic NMDARs using a chemLTP protocol increases GABABR recycling and surface expression. In contrast, excitotoxic global activation of synaptic and extrasynaptic NMDARs by bath application of NMDA causes the loss of surface GABABRs. Intriguingly, exposing neurons to extreme metabolic stress using oxygen/glucose deprivation (OGD) increases GABAB1 but decreases GABAB2 surface expression. The increase in surface GABAB1 involves enhanced recycling and is blocked by the NMDAR antagonist AP5. The decrease in surface GABAB2 is also blocked by AP5 and by inhibiting degradation pathways. These results indicate that NMDAR activity is critical in GABABR trafficking and function and that the individual subunits can be separately controlled to regulate neuronal responsiveness and survival.
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Registered trials
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