ArticleInvestigative ophthalmology & visual science2014
Classification of human retinal microaneurysms using adaptive optics scanning light ophthalmoscope fluorescein angiography.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Deep learning-based optical coherence tomography and retinal images for detection of diabetic retinopathy: a systematic and meta analysis.Frontiers in endocrinology · 2025Pooled it
- Automated Volumetric Segmentation of Microaneurysms on OCT Using Artificial Intelligence.ArXiv · 2026Article
- Microaneurysm segmentation in early diabetic retinopathy: a localized patch-based U-Net approach to overcome microscopic lesion oversight.International journal of retina and vitreous · 2026Article
- Reflective broadband adaptive optics scanning light ophthalmoscope with 20 D focus range.Biomedical optics express · 2026Article
- Automated interpretation of fundus fluorescein angiography with multi-retinal vascular lesion segmentation.Frontiers in medicine · 2026Article
- Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification.Scientific reports · 2025Article
- Diabetic retinopathy screening using machine learning: a systematic review.BMC biomedical engineering · 2025Article
- Microaneurysm Counting as a Biomarker for the Hyperperfusion Stage of Nonproliferative Diabetic Retinopathy.Ophthalmology and therapy · 2025Article
- Vascular Perfusion Variability in Diabetic Retinopathy: A Sequential Interscan Optical Coherence Tomography Angiography Assessment.Journal of clinical medicine · 2025Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- Digital histology of retinal microaneurysms as provided by dense B-scan (DART) OCTA: characteristics and clinical relevance in diabetic retinopathy.Eye (London, England) · 2024Observational
- Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory.Frontiers in endocrinology · 2024Article
- Perfused and Nonperfused Microaneurysms Identified and Characterized by Structural and Angiographic OCT.ArXiv · 2023Article
- Confocal microscopy of telangiectatic capillaries (TelCaps) and other features of microvascular remodeling following branch retinal vein occlusion.Journal of anatomy · 2023Article
- Enhancement of Diabetic Retinopathy Prognostication Using Deep Learning, CLAHE, and ESRGAN.Diagnostics (Basel, Switzerland) · 2023Article
- Confocal MultiColor Signal Depends on Perfusion Characteristics of Retinal Microaneurysms in Diabetic Retinopathy as Detected by OCTA.Translational vision science & technology · 2023Observational
- Deep Learning-Based Prediction of Diabetic Retinopathy Using CLAHE and ESRGAN for Enhancement.Healthcare (Basel, Switzerland) · 2023Article
- Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited].Biomedical optics express · 2023Review
- Intraretinal Macroaneurysms and Multimodal Imaging: A Retrospective Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Three-Dimensional Semantic Segmentation of Diabetic Retinopathy Lesions and Grading Using Transfer Learning.Journal of personalized medicine · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
purposeMicroaneurysms (MAs) are considered a hallmark of retinal vascular disease, yet what little is known about them is mostly based upon histology, not clinical observation. Here, we use the recently developed adaptive optics scanning light ophthalmoscope (AOSLO) fluorescein angiography (FA) to image human MAs in vivo and to expand on previously described MA morphologic classification schemes.
methodsPatients with vascular retinopathies (diabetic, hypertensive, and branch and central retinal vein occlusion) were imaged with reflectance AOSLO and AOSLO FA. Ninety-three MAs, from 14 eyes, were imaged and classified according to appearance into six morphologic groups: focal bulge, saccular, fusiform, mixed, pedunculated, and irregular. The MA perimeter, area, and feret maximum and minimum were correlated to morphology and retinal pathology. Select MAs were imaged longitudinally in two eyes.
resultsAdaptive optics scanning light ophthalmoscope fluorescein angiography imaging revealed microscopic features of MAs not appreciated on conventional images. Saccular MAs were most prevalent (47%). No association was found between the type of retinal pathology and MA morphology (P = 0.44). Pedunculated and irregular MAs were among the largest MAs with average areas of 4188 and 4116 μm(2), respectively. Focal hypofluorescent regions were noted in 30% of MAs and were more likely to be associated with larger MAs (3086 vs. 1448 μm(2), P = 0.0001).
conclusionsRetinal MAs can be classified in vivo into six different morphologic types, according to the geometry of their two-dimensional (2D) en face view. Adaptive optics scanning light ophthalmoscope fluorescein angiography imaging of MAs offers the possibility of studying microvascular change on a histologic scale, which may help our understanding of disease progression and treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.