ReviewAdvances in nutrition (Bethesda, Md.)2014
Adiposity and fat metabolism in lactating and fasting northern elephant seals.
Review in Advances in nutrition (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Elephant Seal Blubber Under Multiple Stressors: Persistent Organic Pollutants, Stress Hormones and Hydrostatic Pressure Alter Transcriptome, Lipolysis and Leptin Secretion.Environmental science & technology · 2026Article
- The plasma proteome reveals markers of recent and repeated stress in free-ranging seals.Conservation physiology · 2024Article
- Adrenal response to ACTH challenge alters thyroid and immune function and varies with body reserves in molting adult female northern elephant seals.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Effects of disease on foraging behaviour and success in an individual free-ranging northern elephant seal.Conservation physiology · 2023Article
- Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal.Frontiers in physiology · 2022Article
- Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Metabolic response of dolphins to short-term fasting reveals physiological changes that differ from the traditional fasting model.The Journal of experimental biology · 2021Article
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- Blubber transcriptome responses to repeated ACTH administration in a marine mammal.Scientific reports · 2019Article
- Temporal changes in Weddell seal dive behavior over winter: Are females increasing foraging effort to support gestation?Ecology and evolution · 2018Article
- Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups.Physiological genomics · 2018Article
- Adult male northern elephant seals maintain high rates of glucose production during extended breeding fasts.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal.Scientific reports · 2017Article
- Scaling matters: incorporating body composition into Weddell seal seasonal oxygen store comparisons reveals maintenance of aerobic capacities.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Muscle transcriptome response to ACTH administration in a free-ranging marine mammal.Physiological genomics · 2015Article
- Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.General and comparative endocrinology · 2015Article
- Transcriptome analysis of northern elephant seal (Mirounga angustirostris) muscle tissue provides a novel molecular resource and physiological insights.BMC genomics · 2015Article
- Adrenal sensitivity to stress is maintained despite variation in baseline glucocorticoids in moulting seals.Conservation physiology · 2015Article
- Effects of age, adipose percent, and reproduction on PCB concentrations and profiles in an extreme fasting North Pacific marine mammal.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several taxa of animals fast completely from food and water during energy-intensive periods such as lactation, breeding, and development. In elephant seals, these behaviors are sustained by high adiposity, high rates of fat mobilization, and reduced oxidation of carbohydrates and proteins. Adiposity and the regulation of lipolysis directly affect lactation energetics, milk composition, and mating success. Long-term fasting induces changes in regulation of lipolysis and lipid metabolism that influence fatty acid (FA) availability and the onset of insulin resistance. Hypoinsulinemia and elevated circulating FAs are also associated with several unique features of carbohydrate metabolism, including elevated plasma glucose, gluconeogenesis, and Cori cycle activity as well as high rates of pyruvate and tricarboxylic acid cycling. Glucose-lactate pools and triacylglycerol-FA cycles may be linked via glyceroneogenesis and this may be an important pathway influencing both fat and carbohydrate metabolism. Together, these features allow a sustained, high intensity, fat-based metabolism without substantial accumulation of ketoacids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.