Evidence map›Paper›PMID 24425421›Full record

ArticleStem cell reviews and reports2014

The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine.

Ana M Martins, Gordana Vunjak-Novakovic, Rui L Reis

Abstract read
In one paragraph

Article in Stem cell reviews and reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease.Advances in experimental medicine and biology · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Bioengineering Technologies for Cardiac Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Taking Systems Medicine to Heart.Circulation research · 2018
    Review
  15. Article
  16. Article
  17. Culture of iPSCs Derived PancreaticBioMed research international · 2017
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ana M Martins3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães, Portugal.
Gordana Vunjak-Novakovic
Rui L Reis

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
Tissue Chips for Rare Disease: Adding Timothy Syndrome to the HeLIVaSkCa platformUH3EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2014 to 2016
$7.1M
Integrated heart-liver-vascular systems for drug testing in human health and diseUH2EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2012 to 2013
$1.7M
Enhancing survival and function of engineered cardiac tissueR21HL108668 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SANTAMBROGIO, LAURA, VUNJAK-NOVAKOVIC, GORDANA · 2011 to 2012
$461k
NHLBI NIH HHS HL076485NHLBI NIH HHS HL108668NHLBI NIH HHS R01 HL076485NHLBI NIH HHS R21 HL108668NIBIB NIH HHS EB 002520NIBIB NIH HHS EB 17103NIBIB NIH HHS P41 EB002520NIBIB NIH HHS UH2 EB017103NIBIB NIH HHS UH3 EB017103
6 · The paper itself

Abstract

The recent availability of human cardiomyocytes derived from induced pluripotent stem (iPS) cells opens new opportunities to build in vitro models of cardiac disease, screening for new drugs, and patient-specific cardiac therapy. Notably, the use of iPS cells enables studies in the wide pool of genotypes and phenotypes. We describe progress in reprogramming of induced pluripotent stem (iPS) cells towards the cardiac lineage/differentiation. The focus is on challenges of cardiac disease modeling using iPS cells and their potential to produce safe, effective and affordable therapies/applications with the emphasis of cardiac tissue engineering. We also discuss implications of human iPS cells to biological research and some of the future needs.

Indexed as

Tissue EngineeringAnimalsCell DifferentiationCells, CulturedGlycogen Storage DiseaseHeart DiseasesHumansInduced Pluripotent Stem CellsModels, BiologicalMyocytes, CardiacRegenerative Medicine

Identifiers

PMID24425421
PMCPMC4476262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.