ArticleJournal of the American Society for Mass Spectrometry2014
Multi-component ion modifiers and arcing suppressants to enhance differential mobility spectrometry for separation of peptides and drug molecules.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid.Journal of lipid research · 2019Article
- Differential Mobility Spectrometry for Improved Selectivity in Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry Analysis of Paralytic Shellfish Toxins.Journal of the American Society for Mass Spectrometry · 2017Article
- Characterization of Complete Histone Tail Proteoforms Using Differential Ion Mobility Spectrometry.Analytical chemistry · 2017Article
- To What Extent is FAIMS Beneficial in the Analysis of Proteins?Journal of the American Society for Mass Spectrometry · 2016Article
- Description of gas-phase ion/neutral interactions in differential ion mobility spectrometry: CV prediction using calibration runs.Journal of the American Society for Mass Spectrometry · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
The optimization of ion/molecule chemistry in a differential mobility spectrometer (DMS) is shown to result in improved peak capacity, separation, and sensitivity. We have experimented with a modifier composed of multiple components, where each component accomplishes a specific task on mixtures of peptides and small drug molecules. Use of a higher proton affinity modifier (hexanol) provides increased peak capacity and separation. Analyte ion/modifier proton transfer is suppressed by adding a large excess of low proton affinity modifier (water or methanol), significantly increasing signal intensity and sensitivity for low proton affinity analytes. Finally, addition of an electrical arcing suppressant (chloroform) allows the device to operate reliably at higher separation fields, improving peak capacity and separation. We demonstrate a 20% increase in the device peak capacity without any loss of sensitivity and estimate that further optimization of the modifier composition can increase this to 50%. Use of 3-, 4-, or even 5-component modifiers offers the opportunity for the user to fine-tune the modifier performance to maximize the device performance, something not possible with a single component modifier.
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Registered trials
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