ArticleStroke2014
Thrombelastography detects the anticoagulant effect of rivaroxaban in patients with stroke.
Article in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02651909 (Utilization of Thromboelastography to Monitor Rivaroxaban Activity in Trauma and Emergency Surgery Patients), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utilization of Thromboelastography to Monitor Rivaroxaban Activity in Trauma and Emergency Surgery Patients
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- The investigation on the hypercoagulability of hepatocellular carcinoma-related cerebral infarction with thromboelastography.Brain and behavior · 2023Article
- Global thromboelastometry in patients receiving direct oral anticoagulants: the RO-DOA study.Journal of thrombosis and thrombolysis · 2020Article
- A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.Journal of thrombosis and haemostasis : JTH · 2019Article
- A prospective evaluation of rivaroxaban on haemostatic parameters in apparently healthy dogs.Veterinary medicine and science · 2019Article
- Diagnostic accuracy of thromboelastometry and its correlation with the HPLC-MS/MS quantification test.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal.Current neurology and neuroscience reports · 2017Review
- In vitro reversal of supratherapeutic rivaroxaban levels with coagulation factor concentrates.Blood transfusion = Trasfusione del sangue · 2016Article
- Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.Journal of thrombosis and haemostasis : JTH · 2016Article
- Reversal of anticoagulant effects in patients with intracerebral hemorrhage.Current neurology and neuroscience reports · 2015Review
- Global assays of hemostasis.Current opinion in hematology · 2014Review
- Emergency reversal of anticoagulation: novel agents.Current neurology and neuroscience reports · 2014Review
- Clinical Application of Thromboelastography in Acute Ischemic Stroke.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
- Monitoring of Rivaroxaban Therapy in Hypercoagulable Dogs.Journal of veterinary internal medicineArticle
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7 authors.
Funding
Abstract
background and purposeFactor Xa inhibitors are prescribed for stroke prevention in atrial fibrillation. Managing such patients is challenging especially if they are eligible for thrombolysis because there is no rapidly available test to detect the effect of such medications. Thrombelastography analyzes the dynamics of coagulation and can be rapidly performed. We sought to determine whether thrombelastography can detect the anticoagulation effect of factor Xa inhibitors in patients with stroke.
methodsBlood from 10 patients with stroke was analyzed by thrombelastography at baseline and 2 to 18 hours after rivaroxaban administration.
resultsIncreased R, K, and δ were seen at 2, 4, and 6 hours, while G, maximum amplitude, α-angle, and LY30 were decreased. Baseline R was 5.8±0.5 when compared with 11.4±1.0 at 2 hours. R remained prolonged at 18 hours. Other thrombelastography parameters were normal by 18 hours.
conclusionsThrombelastography can detect the anticoagulant effect of factor Xa inhibitors in patients with stroke and might be useful in the emergency management of those eligible for thrombolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.