ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Effects of AFP-activated PI3K/Akt signaling pathway on cell proliferation of liver cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- AFP Stimulates Glucose Metabolic Reprogramming Contributing to Hepatocellular Carcinoma Resist Sorafenib Through Activating PI3K/AKT Signalling Pathway.Journal of cellular and molecular medicine · 2026Article
- Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking andFrontiers in oncology · 2025Article
- Association of serum AFP trajectories and hepatocellular carcinoma outcomes after hepatic arterial infusion chemotherapy: A longitudinal, multicenter study.Cancer medicine · 2024Article
- Study of siRNA Delivery via Polymeric Nanoparticles in Combination with Angiogenesis Inhibitor for The Treatment ofInternational journal of molecular sciences · 2022Article
- Clinical risk factors of carbohydrate antigen-125, cytokeratin fragment 19, and neuron-specific enolase in liver metastases from elderly lung cancer patients.Frontiers in genetics · 2022Article
- Component Identification of Phenolic Acids in Cell Suspension Cultures ofFoods (Basel, Switzerland) · 2021Article
- Integrated analysis of the rhesus monkey liver transcriptome during development and human primary HCC AFP-related gene expression.Molecular therapy. Nucleic acids · 2021Article
- Identification of Clinical Phenotypes and Related Survival in Patients with Large HCCs.Cancers · 2021Article
- Comparison of Transcriptomics Changes Induced by TCS and MTCS Exposure in Human Hepatoma HepG2 Cells.ACS omega · 2020Article
- Article
- Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT.The Journal of international medical research · 2018Article
- Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients.Cancer biomarkers : section A of Disease markers · 2018Article
- Total Flavonoids fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- [A preliminary study of retinoblastoma-related serum tumor markers].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Expression and Significances of G-Protein-Coupled Receptor Kinase 3 in Hepatocellular Carcinoma.Journal of Cancer · 2017Article
- Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells.Oncotarget · 2016Article
- Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells.Journal of cellular and molecular medicine · 2016Article
- Hepatitis B Virus X Protein Driven Alpha Fetoprotein Expression to Promote Malignant Behaviors of Normal Liver Cells and Hepatoma Cells.Journal of Cancer · 2016Article
- Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate effects of alpha-fetoprotein (AFP)-activated phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway on hepatocellular carcinoma cell proliferation. Active cirrhosis patients after hepatitis B infection (n = 20) and viral hepatitis patients with hepatocellular carcinoma (HCC) (n = 20) were selected as the subjects of the present study. Another 20 healthy subjects were selected as the control group. The serum AFP expression and liver tissue PI3K and Akt gene mRNA expression were detected. The hepatoma cell model HepG2 which had a stable expression of AFP gene was used. Real-time quantitative PCR and Western blot and other methods were used to analyze the intracellular PI3K and Akt protein levels. Compared with control group and cirrhosis group, the serum AFP levels in HCC group significantly increased, and the tissue PI3K and Akt mRNA expression also significantly increased. HepG2 cells were intervened using AFP, in which the PIK and Akt protein expression significantly increased. After intervention by use of AFP monoclonal antibodies or LY294002 inhibitor, the PIK and Akt protein expression in HepG2 cell was significantly decreased (P < 0.05). AFP can promote the proliferation of hepatoma cells via activation of PI3K/Akt signaling pathway.
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