Evidence map›Paper›PMID 24424790›Full record

SynthesisPediatric blood & cancer2014

A systematic review of dental late effects in survivors of childhood cancer.

Prasad L Gawade, Melissa M Hudson, Sue C Kaste, Joseph P Neglia, Louis S Constine, Leslie L Robison, Kirsten K Ness

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Pediatric blood & cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.

  1. Best clinical practise guidance for oral health care management of long-term childhood cancer survivors (CCS): an EAPD policy document.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Guideline
  2. Dental management of long-term childhood cancer survivors: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024
    Pooled it
  3. Association between tooth agenesis and cancer: a systematic review.Journal of applied oral science : revista FOB · 2021
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Dental treatment approaches under general anesthesia in children with cancer.Medicina oral, patologia oral y cirugia bucal · 2025
    Article
  8. Article
  9. Article
  10. Temporomandibular Joint and Dental Complications in Long-Term Survivors of Children with Leukemia after Chemoradiotherapy and Stem Cell Transplantation.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  11. Article
  12. Article
  13. Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Prasad L GawadeDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, 38105.
Melissa M Hudson
Sue C Kaste
Joseph P Neglia
Louis S Constine
Leslie L Robison
Kirsten K Ness
St. Jude Children's Research Hospital · USUniversity of Minnesota Medical Center · USUniversity of Rochester Medical Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS CA 21765NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

Survivors of childhood cancer are at risk for dental late effects. This systematic review summarizes associations between treatment exposures and dental late effects among survivors of childhood cancer. We included investigations with at least 20 study participants conducted for 2 or more years after completion of childhood, adolescent, or young adult cancer therapy. This review suggests both independent and additive effects of radiotherapy and chemotherapy on dental complications, and identifies vulnerable groups with specific host and treatment characteristics. This summary provides information that will assist clinicians to prevent, detect, and facilitate early intervention for dental late effects.

Indexed as

Antineoplastic AgentsChildDental CariesHematopoietic Stem Cell TransplantationHumansNeoplasmsRadiotherapySurvivorsTooth AbnormalitiesAntineoplastic Agentschemotherapypediatricsradiotherapytooth abnormalities

Identifiers

PMID24424790
PMCPMC4281834
OpenAlexW2115100758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.