ArticleJournal of oncology practice2014
Use of the National Cancer Institute Community Cancer Centers Program screening and accrual log to address cancer clinical trial accrual.
Article in Journal of oncology practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- "When Offered to Participate": A Systematic Review and Meta-Analysis of Patient Agreement to Participate in Cancer Clinical Trials.Journal of the National Cancer Institute · 2021Pooled it
- Systematic Review and Meta-Analysis of the Magnitude of Structural, Clinical, and Physician and Patient Barriers to Cancer Clinical Trial Participation.Journal of the National Cancer Institute · 2019Pooled it
- The implementation and utility of patient screening logs in a multicentre randomised controlled oncology trial.Trials · 2020Trial
- Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement.Blood · 2025Article
- Facilitation of Enrollment onto Cancer Clinical Trials Using a Novel Navigator-Assisted Program: A Cross-Sectional Study.Current oncology (Toronto, Ont.) · 2024Article
- Patiromer to Reduce Albuminuria Through Increased Renin Angiotensin Aldosterone System Inhibition in Patients With CKD-A Feasibility Trial.Kidney international reports · 2024Article
- Barriers to Clinical Trial Implementation Among Community Care Centers.JAMA network open · 2024Article
- Eligibility criteria in clinical trials in breast cancer: a cohort study.BMC medicine · 2023Article
- The MATE trial: a multicentre, mixed-methodology, pilot, randomised controlled trial in neovascular age-related macular degeneration.Pilot and feasibility studies · 2023Article
- Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers.Contemporary clinical trials communications · 2022Article
- Demographic and Health Behavior Factors Associated With Clinical Trial Invitation and Participation in the United States.JAMA network open · 2021Article
- Eligibility of real-world patients with metastatic breast cancer for clinical trials.Breast (Edinburgh, Scotland) · 2020Article
- Discordant attitudes and beliefs about cancer clinical trial participation between physicians, research staff, and cancer patients.Clinical trials (London, England) · 2020Article
- Barriers to accrual and enrollment in brain tumor trials.Neuro-oncology · 2019Review
- Association of Patient Comorbid Conditions With Cancer Clinical Trial Participation.JAMA oncology · 2019Article
- Randomized Trials of Proton Therapy: Why They Are at Risk, Proposed Solutions, and Implications for Evaluating Advanced Technologies to Diagnose and Treat Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- Article
- Impact of Eligibility Criteria on Participant Enrollment for a Randomized Clinical Trial of Gonorrhea Treatment.Sexually transmitted diseases · 2017Article
- Observational
- Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
purposeScreening logs have the potential to help oncology clinical trial programs at the site level, as well as trial leaders, address enrollment in real time. Such an approach could be especially helpful in improving representation of racial/ethnic minority and other underrepresented populations in clinical trials.
methodsThe National Cancer Institute Community Cancer Centers Program (NCCCP) developed a screening log. Log data collected from March 2009 through May 2012 were analyzed for number of patients screened versus enrolled, including for demographic subgroups; screening methods; and enrollment barriers, including reasons for ineligibility and provider and patient reasons for declining to offer or participate in a trial. User feedback was obtained to better understand perceptions of log utility.
resultsOf 4,483 patients screened, 18.4% enrolled onto NCCCP log trials. Reasons for nonenrollment were ineligibility (51.6%), patient declined (25.8%), physician declined (15.6%), urgent need for treatment (6.6%), and trial suspension (0.4%). Major reasons for patients declining were no desire to participate in trials (43.2%) and preference for standard of care (39%). Major reasons for physicians declining to offer trials were preference for standard of care (53%) and concerns about tolerability (29.3%). Enrollment rates onto log trials did not differ between white and black (P = .15) or between Hispanic and non-Hispanic patients (P = .73). Other races had lower enrollment rates than whites and blacks. Sites valued the ready access to log data on enrollment barriers, with some sites changing practices to address those barriers.
conclusionUse of screening logs to document enrollment barriers at the local level can facilitate development of strategies to enhance clinical trial accrual.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.