ArticleMenopause (New York, N.Y.)2014
Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.
Article in Menopause (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- FMR1 genotype interacts with parenting stress to shape health and functional abilities in older age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Trial
- The association of CGG repeat length and AGG interruption patterns on FMR1 alleles with female infertility.Frontiers in endocrinology · 2025Article
- IsFrontiers in psychiatry · 2021Article
- Molecular Characterization of FMR1 Gene by TP-PCR in Women of Reproductive Age and Women with Premature Ovarian Insufficiency.Molecular diagnosis & therapy · 2018Article
- Curvilinear Association Between Language Disfluency andFrontiers in genetics · 2018Article
- Expanded alleles of theBioscience reports · 2017Article
- Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters.Journal of assisted reproduction and genetics · 2016Article
- Is FMR1 CGG repeat length a predictor of in vitro fertilization stimulation response or outcome?Fertility and sterility · 2016Article
- Evidence of an age-related correlation of ovarian reserve and FMR1 repeat number among women with "normal" CGG repeat status.Journal of assisted reproduction and genetics · 2015Article
- AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.Journal of assisted reproduction and genetics · 2014Article
- Maximizing the clinical utility of antimüllerian hormone testing in women's health.Current opinion in obstetrics & gynecology · 2014Review
- The FMR1 gene, infertility, and reproductive decision-making: a review.Frontiers in genetics · 2014Review
- Article
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Authors and funding
6 authors.
Funding
Abstract
objectivePremutation and intermediate CGG repeat length at the fragile X mental retardation 1 (FMR1) locus have been associated with premature ovarian failure. We tested whether intermediate length is associated with indicators of ovarian age in a sample of fertile women. Our primary measures of ovarian age were antimüllerian hormone (AMH) and follicle-stimulating hormone (FSH) levels.
methodsThe cross-sectional sample comprised 258 women with karyotyped spontaneous abortions (140 trisomic spontaneous abortions and 118 chromosomally normal spontaneous abortions or spontaneous abortions with anomalies other than trisomy) and 325 women with recent live births (LBs). We analyzed data from the total sample and data from LBs only. We defined CGG repeat length by the length (both continuous and categorical) on the longer allele.
resultsCGG repeat length was not significantly associated with either hormone measure. A repeat length of 35 to 54 CGG, versus the modal category of 30 CGG, was associated with an approximately 7% increase in median AMH level and a 3% increase in median FSH level. Results were unaltered when analyses were limited to LBs. Analyses of hormone levels using cutpoints to define older ovarian age showed no associations with repeat length. Among 10 women with repeat lengths of 35 to 54 CGG analyzed for AGG sequences, the uninterrupted CGG length was not significantly longer among women with hormonal indicators of "old" versus "young" ovarian age.
conclusionsOur data do not support an association between intermediate CGG repeat length and levels of AMH or FSH among fertile women.
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