ArticleJournal of applied clinical medical physics2014
A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: a technical and case report.
Article in Journal of applied clinical medical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Recommendations of the Spanish brachytherapy group (GEB) of Spanish Society of Radiation Oncology (SEOR) and the Spanish Society of Medical Physics (SEFM) for high-dose rate (HDR) non melanoma skin cancer brachytherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Guideline
- Monte Carlo modeling of radiation dose from radiation therapy with superficial x-rays.Journal of applied clinical medical physics · 2025Article
- Intraoperative radiation therapy with 50 kV x-rays: A multi-institutional review.Journal of applied clinical medical physics · 2024Review
- Midterm Results of High-Dose-Rate Intraoperative Brachytherapy in the Treatment of Soft Tissue Sarcomas.Cancers · 2023Article
- Review
- Intraoperative radiation therapy for locally advanced and recurrent head and neck cancer.Molecular and clinical oncology · 2022Article
- Evaluation of dose distribution of an intraoperative radiotherapy device using thermoluminescent dosimeters and radiographic films.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Future directions on low-energy radiation dosimetry.Scientific reports · 2021Article
- Single-Fraction Adjuvant Electronic Brachytherapy after Resection of Conjunctival Carcinoma.Cancers · 2021Article
- Intraoperative radiotherapy with low energy x-rays for primary and recurrent soft-tissue sarcomas.Radiation oncology (London, England) · 2020Article
- Dosimetric characteristics of the INTRABEAM ® system with spherical applicators in the presence of air gaps and tissue heterogeneities.Radiation and environmental biophysics · 2020Article
- Determination of paramagnetic ferrous gel sensitivity in low energy x-ray beam produced by a miniature accelerator.PloS one · 2020Article
- Laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for locally advanced ultra-low rectal cancer.World journal of surgical oncology · 2018Article
- System and path planning algorithm for low-kV X-ray free-form surface irradiation.The international journal of medical robotics + computer assisted surgery : MRCAS · 2018Article
- Intraoperative Radiotherapy With INTRABEAM: Technical and Dosimetric Considerations.Frontiers in oncology · 2018Article
- Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting : Current and Future Application of Intraoperative Radiotherapy (IORT) in the Curative and Palliative Treatment of Breast Cancer.Annals of surgical oncology · 2017Article
- Present state and issues in IORT Physics.Radiation oncology (London, England) · 2017Review
- Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects.Radiation oncology (London, England) · 2017Review
- Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.Frontiers in oncology · 2017Review
- Optimum radiation source for radiation therapy of skin cancer.Journal of applied clinical medical physics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of IORT as a treatment modality for patients with close or positive margins has increased over the past decade. For situations where a flat area (up to 6 cm in diameter) has to be treated intraoperatively, new applicators for superficial treatment with a miniature X-ray source (INTRABEAM system) were developed. Here we report our evaluation of the dosimetric characteristics of these new applicators and their first clinical use. Each of these flat and surface applicators consists of a radiation protective metal tube and a flattening filter, which converts the spherical dose distribution of the X-ray source into a flat one. The homogeneity of each dose distribution and depth-dose measurements were evaluated using film dosimetry in a solid water phantom and a soft X-ray ionization chamber in a water tank. The first patient was treated with 5 Gy delivered in 5 mm using a 4 cm FLAT applicator over 21 minutes. The flat applicators show the maximum homogeneity, with a uniformity ratio of 1.02-1.08 in certain depths. In 1 mm depth surface applicators show a uniformity ratio of 1.15-1.28. They also show a higher dose rate and a steeper dose gradient compared to the flat applicators. The results of this investigation demonstrated that the flat and surface applicators have unique dosimetric characteristics that need to be considered during the treatment planning stages. This work also showed that it is possible to perform a superficial localized IORT which provides new application possibilities for use of the INTRABEAM system.
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