ArticleJournal of vascular surgery2014
Walking disability in patients with peripheral artery disease is associated with arterial endothelial function.
Article in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- A Doppler Ultrasound Method to Measure Vascular Responses to Walking.bioRxiv : the preprint server for biology · 2025Article
- Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.Stem cell research & therapy · 2025Article
- Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China.Frontiers in public health · 2025Article
- Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations.American journal of preventive cardiology · 2022Review
- Update on the pathophysiology and medical treatment of peripheral artery disease.Nature reviews. Cardiology · 2022Review
- Review
- Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship.Biomedicines · 2021Review
- AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease.Irish journal of medical science · 2020Article
- The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins.Antioxidants (Basel, Switzerland) · 2020Article
- Physical Activity Levels in Peripheral Artery Disease Patients.Arquivos brasileiros de cardiologia · 2019Article
- Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease.Antioxidants (Basel, Switzerland) · 2018Review
- The relationship of renal function to segmental vascular stiffness, ankle-brachial index, and peripheral artery disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Growth Hormone (GH) and Cardiovascular System.International journal of molecular sciences · 2018Review
- Imaging in Vascular Access.Cardiovascular engineering and technology · 2017Review
- Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease.Frontiers in physiology · 2017Review
- Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans.Journal of the American Heart Association · 2016Observational
- PAD in women: the ischemic continuum.Current atherosclerosis reports · 2015Review
- A review of the pathophysiology and potential biomarkers for peripheral artery disease.International journal of molecular sciences · 2015Review
- Relationship between kidney disease and endothelial function in peripheral artery disease.Journal of vascular surgery · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePatients with peripheral artery disease (PAD) have varying degrees of walking disability that do not completely correlate with ankle-brachial index (ABI) or angiographic anatomy. We hypothesized that endothelial function (EF) is an independent predictor of symptom severity in PAD patients.
methodsThis was a cross-sectional study of 100 PAD patients presenting to a vascular surgery clinic. All patients received ABI testing and brachial artery flow-mediated, endothelium-dependent vasodilation (FMD) to assess arterial EF. Symptom severity and walking disability reported by Rutherford category was based on the patient's self-report during the clinic visit and recorded by the investigator-vascular surgeons. Demographic, biochemical, and physiologic parameters were entered into regression equations to determine association with symptom severity.
resultsPatients were a mean age of 66 ± 8 years, and 43% had diabetes. Mean FMD was 7.4%, indicating impaired EF. EF progressively declined as Rutherford category increased (P = .01). Brachial artery FMD, ABI, systolic blood pressure, C-reactive protein, low-density lipoprotein, high-density lipoprotein, β-blocker use, and a history of diabetes or coronary artery disease were all associated with Rutherford category (all P < .05). Multivariable regression showed EF (P < .02) and ABI (P < .0001) were independently associated with walking disability. When the cohort was restricted to claudicant patients (n = 73), EF remained associated with walking disability after adjustment for other covariates (P = .0001).
conclusionsSymptom severity in PAD is multifactorial, reflecting impaired hemodynamics and vascular dysfunction. This is the first report demonstrating that walking disability in PAD is associated with arterial EF. The mechanistic link underlying these observations remains to be defined.
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