ReviewInternational review of psychiatry (Abingdon, England)2013
Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia.
Review in International review of psychiatry (Abingdon, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative analysis of white matter signal alterations in dementia with Lewy bodies and Alzheimer's disease: a systematic review and meta-analysis.Frontiers in radiology · 2025Pooled it
- Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia.The Cochrane database of systematic reviews · 2022Pooled it
- Interrelationships between Refined Carbohydrates, Periodontal Diseases, and Cognitive Decline: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2026Review
- Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities.The journal of prevention of Alzheimer's disease · 2025Article
- Intra-voxel angular dispersion of fibers in corpus callosum decreases with healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Prevalence and imaging characteristics of cerebral small vessel disease in a Colombian population aged 40 years and older.Brain communications · 2024Article
- White matter hyperintensity shape is associated with long-term dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Exploring the ATN classification system using brain morphology.Alzheimer's research & therapy · 2023Article
- Leukoaraiosis as a Predictor of Depression and Cognitive Impairment among Stroke Survivors: A Systematic Review.Neurology international · 2023Review
- Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults.Nutrients · 2022Article
- Longitudinal white matter hyperintensity changes and cognitive decline in patients with minor stroke.Aging clinical and experimental research · 2022Article
- Cortical Short-Range Fiber Connectivity and Its Association With Deep Brain White Matter Hyperintensities in Older Diabetic People With Low Serum Vitamin BFrontiers in aging neuroscience · 2022Article
- Observational
- Physical activity moderates the association between white matter hyperintensity burden and cognitive change.Frontiers in aging neuroscience · 2022Article
- Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.Journal of affective disorders · 2021Article
- Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Spatial distribution and cognitive impact of cerebrovascular risk-related white matter hyperintensities.NeuroImage. Clinical · 2020Article
- Age-dependent association of white matter abnormality with cognition after TIA or minor stroke.Neurology · 2019Article
- Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening.Journal of healthcare engineering · 2019Article
- Executive Functions in Healthy Older Adults Are Differentially Related to Macro- and Microstructural White Matter Characteristics of the Cerebral Lobes.Frontiers in aging neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral white matter hyperintensities (WMH), detected in vivo with magnetic resonance imaging (MRI), are commonly used to assess cerebrovascular burden in cognitive impairment. However, the association between WMH and cognition is not consistent across the literature. The present review examines evidence from published longitudinal studies. We reviewed the PubMed data base from January 1990 to March 2013 and included studies investigating the association of WMH with (1) the risk of dementia in the general population, (2) the risk of conversion to dementia in the mild cognitive impairment (MCI) population, and (3) cognitive decline in the general population. WMH were associated with all types of dementia in the general population, but not in MCI patients. Results are discrepant for global decline. WMH appear to be early predictors of the risk of dementia, but this association appears to be modulated by cognitive reserve, age and the spatial distribution of lesions. There are, however, some limits in the use of WMH as a marker of vascular burden. In addition to their ischaemic origin, WMH may be the result of co-occurring morbidity. Further research is needed to elucidate to what extent WMH actually reflect vascular risk to evaluate the likely efficacy of interventions specifically targeting WMH reduction.
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