ArticleBMC plant biology2014
Ectopic expression of the phosphomimic mutant version of Arabidopsis response regulator 1 promotes a constitutive cytokinin response phenotype.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Rational Modulation of Plant Root Development Using Engineered Cytokinin Regulators.ACS synthetic biology · 2025Article
- CRISPR-mediated mutation of cytokinin signaling genes (SlHP2 and SlHP3) in tomato: Morphological, physiological, and molecular characterization.The plant genome · 2025Article
- The TATA-box binding protein-associated factor TAF12b facilitates the degradation of type B response regulators to negatively regulate cytokinin signaling.Plant communications · 2024Article
- Gain-of-function of the cytokinin response activator ARR1 increases heat shock tolerance inPlant signaling & behavior · 2022Article
- Identification of BcARR Genes and CTK Effects on Stalk Development of Flowering Chinese Cabbage.International journal of molecular sciences · 2022Article
- Auxin/Cytokinin Antagonistic Control of the Shoot/Root Growth Ratio and Its Relevance for Adaptation to Drought and Nutrient Deficiency Stresses.International journal of molecular sciences · 2022Review
- Histidine kinase inhibitors impair shoot regeneration inFrontiers in plant science · 2022Article
- The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.The Plant cell · 2020Article
- Role and Regulation of Cytokinins in Plant Response to Drought Stress.Plants (Basel, Switzerland) · 2020Review
- Role of the Cytokinin-Activated Type-B Response Regulators in Hormone Crosstalk.Plants (Basel, Switzerland) · 2020Review
- Antagonistic activity of auxin and cytokinin in shoot and root organs.Plant direct · 2019Article
- Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development inProceedings of the National Academy of Sciences of the United States of America · 2017Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCytokinins control numerous plant developmental processes, including meristem formation and activity, nutrient distribution, senescence timing and responses to both the abiotic and biotic environments. Cytokinin signaling leads to the activation of type-B response regulators (RRBs), Myb-like transcription factors that are activated by the phosphorylation of a conserved aspartate residue in their response receiver domain. Consistent with this, overexpression of RRBs does not substantially alter plant development, but instead leads to cytokinin hypersensitivity.
resultsHere we present comparative analysis of plants overexpressing Arabidopsis RRB 1 (ARR1) or a phosphomimic ARR1D94E mutant in which the conserved aspartate-94 (D94) is replaced by the phosphomimic residue glutamate (E). The D94E substitution causes a 100-fold increase in response activation and instigates developmental and physiological changes that characterize wild-type plants treated with cytokinins or transgenic plants with increased cytokinin content.
conclusionThe current model of cytokinin signaling emphasizes the essential role of conserved aspartate residue phosphorylation of RRBs in promoting cytokinin responses. Our comparative analyses of developmental and physiological traits of ARR1 and ARR1D94E overexpressing plants revealed that the ARR1D94E protein is indeed a constitutive and wide-spectrum cytokinin response activator.
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