ArticleBMC neuroscience2014
New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development.
Article in BMC neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Olig1/2 Orchestrates Progenitor Cell Fates during Mammalian Cortical Gliogenesis and Gliomagenesis.Nature communications · 2025Article
- Article
- Gene expression changes in the brain of a Cushing's syndrome mouse model.Journal of neuroendocrinology · 2022Article
- Review
- The Effects of the Olig Family on the Regulation of Spinal Cord Development and Regeneration.Neurochemical research · 2021Review
- Oligodendrocyte Development and Regenerative Therapeutics in Multiple Sclerosis.Life (Basel, Switzerland) · 2021Review
- More attention on glial cells to have better recovery after spinal cord injury.Biochemistry and biophysics reports · 2021Review
- Impact of the Olig Family on Neurodevelopmental Disorders.Frontiers in neuroscience · 2021Review
- Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats.Molecular medicine reports · 2019Article
- Molecular Control of Oligodendrocyte Development.Trends in neurosciences · 2019Review
- Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Evolution of the CNS myelin gene regulatory program.Brain research · 2016Review
- Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration.Brain research · 2016Review
- Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Oligodendrocyte Development and Plasticity.Cold Spring Harbor perspectives in biology · 2015Review
- Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.Genes & development · 2015Article
- Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage.Glia · 2015Review
- Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System.Cold Spring Harbor perspectives in biology · 2015Review
- Olig1 function is required for oligodendrocyte differentiation in the mouse brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis.Journal of central nervous system disease · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOlig1 and Olig2, encoding closely related basic helix-loop-helix transcription factors, were originally identified in screens for glial-specific genes. Olig1 and Olig2 are both expressed in restricted parts of the neuroepithelium of the embryonic spinal cord and telencephalon and subsequently in oligodendrocyte lineage cells throughout life. In the spinal cord, Olig2 plays a crucial role in the development of oligodendrocytes and motor neurons, and both cell types are lost from Olig2 null mutant mice. The role of Olig1 has been more cryptic. It was initially reported that Olig1 null mice (with a Cre-Pgk-Neo cassette at the Olig1 locus) have a mild developmental phenotype characterized by a slight delay in oligodendrocyte differentiation. However, a subsequent study of the same line following removal of Pgk-Neo (leaving Olig1-Cre) found severe disruption of oligodendrocyte production, myelination failure and early postnatal lethality. A plausible explanation was proposed, that the highly expressed Pgk-Neo cassette in the original line might have up-regulated the neighbouring Olig2 gene, compensating for loss of Olig1. However, this was not tested, so the importance of Olig1 for oligodendrocyte development has remained unclear.
resultsWe generated two independent lines of Olig1 null mice. Both lines had a mild phenotype featuring slightly delayed oligodendrocyte differentiation and maturation but no long-term effect. In addition, we found that Olig2 transcripts were not up-regulated in our Olig1 null mice.
conclusionsOur findings support the original conclusion that Olig1 plays a minor and non-essential role in oligodendrocyte development and have implications for the interpretation of studies based on Olig1 deficient mice (and perhaps Olig1-Cre mice) from different sources.
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