Evidence map›Paper›PMID 24422777›Full record

ArticleOrganic letters2014

Asymmetric alcohol C-H allylation and syn-crotylation: C9-C20 of tetrafibricin.

Takahiko Itoh, T Patrick Montgomery, Antonio Recio, Michael J Krische

Abstract read
In one paragraph

Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Total Synthesis ofJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Takahiko ItohUniversity of Texas at Austin , Department of Chemistry and Biochemistry, Austin, Texas 78712, United States.
T Patrick Montgomery
Antonio Recio
Michael J Krische

Funding

Polyketides via Redox-Triggered Alcohol C-H Functionalization.R01GM093905 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KRISCHE, MICHAEL J · 2011 to 2024
$4.5M
NIGMS NIH HHS R01 GM093905NIGMS NIH HHS R01-GM093905
6 · The paper itself

Abstract

The C9-C20 segment of the fibrinogen receptor inhibitor tetrafibricin was prepared in 10 steps (longest linear sequence). Ruthenium catalyzed enantioselective syn-crotylation is used to construct C9-C13. Iridium catalyzed asymmetric alcohol C-H allylation of a commercial malic acid derived alcohol is used to construct C14-C20. Recovery and recycling of the iridium catalyst is described.

Indexed as

AlcoholsCatalysisHydrogen BondingIridiumMacrolidesMolecular StructureReceptors, FibrinogenStereoisomerismAlcoholsIridiumMacrolidesReceptors, Fibrinogentetrafibricin

Identifiers

PMID24422777
PMCPMC3932543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.