ArticleBoneKEy reports2013
The enigmas of bone without osteocytes.
Article in BoneKEy reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- Maintenance of bone health by osteoblasts in the absence of osteocytes: comparative analysis of gene expression in medaka and zebrafish vertebrae.Bone reports · 2026Article
- Nanocrystal Compressive Residual Stresses: A Strategy to Strengthen the Bony Spines of Osteocytic and Anosteocytic Fish.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A novel optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system.Frontiers in endocrinology · 2025Article
- Preclinical Rodent Models for Human Bone Disease, Including a Focus on Cortical Bone.Endocrine reviews · 2024Review
- Cortical and Trabecular Bone Modeling and Implications for Bone Functional Adaptation in the Mammalian Tibia.Bioengineering (Basel, Switzerland) · 2024Review
- A Collagen10a1 mutation disrupts cell polarity in a medaka model for metaphyseal chondrodysplasia type Schmid.iScience · 2024Article
- Osteocyte-mediated mechanical response controls osteoblast differentiation and function.Frontiers in physiology · 2024Review
- Skeletal Morphogenesis and Anomalies in Gilthead Seabream: A Comprehensive Review.International journal of molecular sciences · 2023Review
- The osteocyte and its osteoclastogenic potential.Frontiers in endocrinology · 2023Review
- Muscle regeneration in gilthead sea bream: Implications of endocrine and local regulatory factors and the crosstalk with bone.Frontiers in endocrinology · 2023Article
- Mechanisms of dermal bone repair after predatory attack in the giant stem-group teleost Leedsichthys problematicus Woodward, 1889a (Pachycormiformes).Journal of anatomy · 2022Article
- The complex rostral morphology and the endoskeleton ossification process of two adult samples of Xiphias gladius (Xiphiidae).Journal of fish biology · 2022Article
- Three-dimensional topology optimization model to simulate the external shapes of bone.PLoS computational biology · 2021Article
- Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography.Science advances · 2021Article
- Microstructure, mineral and mechanical properties of teleost intermuscular bones.Journal of biomechanics · 2019Article
- On the Origins of Fracture Toughness in Advanced Teleosts: How the Swordfish Sword's Bone Structure and Composition Allow for Slashing under Water to Kill or Stun Prey.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model.Annals of the New York Academy of Sciences · 2019Article
- A novel nonosteocytic regulatory mechanism of bone modeling.PLoS biology · 2019Article
- Krogh's principle for musculoskeletal physiology and pathology.Journal of musculoskeletal & neuronal interactions · 2018Article
- Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the hallmarks of tetrapod bone is the presence of numerous cells (osteocytes) within the matrix. Osteocytes are vital components of tetrapod bone, orchestrating the processes of bone building, reshaping and repairing (modeling and remodeling), and probably also participating in calcium-phosphorus homeostasis via both the local process of osteocytic osteolysis, and systemic effect on the kidneys. Given these critical roles of osteocytes, it is thought-provoking that the entire skeleton of many fishes consists of bone material that does not contain osteocytes. This raises the intriguing question of how the skeleton of these animals accomplishes the various essential functions attributed to osteocytes in other vertebrates, and raises the possibility that in acellular bone some of these functions are either accomplished by non-osteocytic routes or not necessary at all. In this review, we outline evidence for and against the fact that primary functions normally ascribed to osteocytes, such as mechanosensation, regulation of osteoblast/clast activity and mineral metabolism, also occur in fish bone devoid of these cells, and therefore must be carried out through alternative and perhaps ancient pathways. To enable meaningful comparisons with mammalian bone, we suggest thorough, phylogenetic examinations of regulatory pathways, studies of structure and mechanical properties and surveys of the presence/absence of bone cells in fishes. Insights gained into the micro-/nanolevel structure and architecture of fish bone, its mechanical properties and its physiology in health and disease will contribute to the discipline of fish skeletal biology, but may also help answer questions of basic bone biology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.