Evidence map›Paper›PMID 24421862›Full record

ArticleFuture virology2013

CD4

Matthew F Cusick, Jane E Libbey, Joan Cox Gill, Robert S Fujinami, David D Eckels

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Matthew F CusickDepartment of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.
Jane E LibbeyDepartment of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.
Joan Cox GillBlood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.
Robert S FujinamiDepartment of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.
David D EckelsDepartment of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.
University of Utah · USVersiti Blood Center of Wisconsin · US

Funding

Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
REGULATION OF HUMAN T-CELL IMMUNITY TO HCV ANTIGENSR01AI047347 · NIAID · UNIVERSITY OF UTAH · PI ECKELS, DAVID D · 1999 to 2009
$3.5M
NIAID NIH HHS R01 AI047347NIAID NIH HHS T32 AI055434
6 · The paper itself

Abstract

aimTo determine whether modulation of T-cell responses by naturally occurring viral variants caused an increase in numbers of Tregs in HCV-infected patients. PATIENTS MATERIALS &

methodsHuman peripheral blood mononuclear cells, having proliferative responses to a wild-type HCV-specific CD4

resultsIn combination, the wild-type and variant peptides led to enhanced suppression of an anti-HCV T-cell response. The variant had a lower avidity for the wild-type-specific CD4

conclusionA stable viral variant from a chronic HCV subject was able to induce Tregs in multiple individuals that responded to the wild-type HCV-specific CD4

Indexed as

altered peptide ligandHCVhuman PBMCsregulatory T cells

Identifiers

PMID24421862
PMCPMC3887522
OpenAlexW2044505893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.