ArticleInternational journal of health sciences2013
Effect of transforming growth factor Beta 1 on wound healing in induced diabetic rats.
Article in International journal of health sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 85 citations in OpenAlex.
- Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial.Journal of diabetes research · 2017Trial
- Unraveling the Mechanisms of Diabetic Wounds: Insights into Pathogenesis and Advanced Treatment Strategies.Current diabetes reviews · 2026Review
- Evaluating the effect of fucoidan-alginate combined dressing on wound healing in rats with full-thickness skin removed.Iranian journal of basic medical sciences · 2025Article
- Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in type 2 diabetic Goto-Kakizaki (GK) rats.Frontiers in pharmacology · 2025Article
- Amelioration of full-thickness cutaneous wound healing using stem cell exosome and zinc oxide nanoparticles in rats.Heliyon · 2024Article
- Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts.ACS pharmacology & translational science · 2024Review
- Silver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected withFrontiers in cellular and infection microbiology · 2024Article
- Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines.International journal of molecular sciences · 2023Article
- WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.Cell biology and toxicology · 2023Article
- Various effects of 11,12 EET rescue wound healing in a combined model of diabetes and ischemia.Scientific reports · 2023Article
- Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model.Frontiers in medicine · 2023Article
- Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes.Frontiers in immunology · 2023Review
- Nanofibrous insulin/vildagliptin core-shell PLGA scaffold promotes diabetic wound healing.Frontiers in bioengineering and biotechnology · 2023Article
- Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts.Gels (Basel, Switzerland) · 2022Article
- Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing.Biomedicines · 2022Review
- Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds.Life (Basel, Switzerland) · 2022Article
- Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment.Pharmaceutics · 2022Article
- Article
- Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats.Veterinary medicine and science · 2022Article
- Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDelayed wound healing is one of the complications of diabetes mellitus, exhibited by profound inflammation and decreased granulation tissues. The current study was carried out to evaluate wound healing in both normal and diabetic rats. In addition, it evaluated the potential protective effect of transforming growth factor β1 (TGF β1), that has the broadest spectrum of actions, affecting all cell types that are involved in all stages of wound healing to accelerate wound healing in normal & diabetic rats.
methods: The present study was performed on 40 male albino rats. Each 10 rats were designed as a group. Group I saved as control. They received incisional wound in their tongues 1 cm length and 1/2 cm depth. Group II received 500 ng/kg of TGF β1 5 minutes before wounding. Group III diabetes was induced then rats were treated as second group. At the 14(th) day post wounding, sections of tongues were taken for hematoxylin and eosin and Masson's trichome staining to examine the histological changes. The intracellular actions of TGF β1 were studied by TEM.
resultsA higher cell proliferation rate and a denser and more organized new extracellular matrix and complete wound closure was detected at the 14(th) days in the TGF β1 treated wound in comparison with the 14(th) days for the untreated, control groups. There were delayed wound healing in diabetic rats, decreased re-epithelialization, granulation tissue thickness, matrix density, number of infiltrated cells, and number of capillaries. In TGF β1 treated diabetic rats, showed significant healing improvement was obvious as compared with diabetic rats.
conclusionsA single intravenous injection of TGF β1 was sufficient to enhance wound healing in rat's tongue. This approach represents a new strategy that may be applied to the treatment of incisional wounds in human diabetic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.