ArticleMolecular and cellular biology2014
Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.
Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting.EMBO reports · 2024Article
- Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A.Journal of lipid research · 2022Article
- Review
- Retinol Binding Protein 7 Promotes AdipogenesisFrontiers in cell and developmental biology · 2022Article
- Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin.Molecular biology reports · 2021Article
- Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication.Journal of lipid research · 2019Review
- The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.The Journal of biological chemistry · 2017Article
- Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest).PloS one · 2017Article
- Transport of vitamin A across blood-tissue barriers is facilitated by STRA6.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.Diabetes · 2016Article
- Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Is retinol binding protein 4 a link between adiposity and cancer?Hormone molecular biology and clinical investigation · 2015Review
- STRA6: role in cellular retinol uptake and efflux.Hepatobiliary surgery and nutrition · 2015Review
- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency.The Journal of biological chemistry · 2015Article
- STRA6 is critical for cellular vitamin A uptake and homeostasis.Human molecular genetics · 2014Article
- Reply to "Apo-RBP, Holo-RBP, and insulin resistance".Molecular and cellular biology · 2014Article
- Apo-RBP, holo-RBP, and insulin resistance.Molecular and cellular biology · 2014Article
- Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
To investigate the mechanisms by which elevated retinol-binding protein 4 (RBP4) causes insulin resistance, we studied the role of the high-affinity receptor for RBP4, STRA6 (stimulated by retinoic acid), in insulin resistance and obesity. In high-fat-diet-fed and ob/ob mice, STRA6 expression was decreased 70 to 95% in perigonadal adipocytes and both perigonadal and subcutaneous adipose stromovascular cells. To determine whether downregulation of STRA6 in adipocytes contributes to insulin resistance, we generated adipose-Stra6(-/-) mice. Adipose-Stra6(-/-) mice fed chow had decreased body weight, fat mass, leptin levels, insulin levels, and adipocyte number and increased expression of brown fat-selective markers in white adipose tissue. When fed a high-fat diet, these mice had a mild improvement in insulin sensitivity at an age when adiposity was unchanged. STRA6 has been implicated in retinol uptake, but retinol uptake and the expression of retinoid homeostatic genes (encoding retinoic acid receptor β [RARβ], CYP26A1, and lecithin retinol acyltransferase) were not altered in adipocytes from adipose-Stra6(-/-) mice, indicating that retinoid homeostasis was maintained with STRA6 knockdown. Thus, STRA6 reduction in adipocytes in adipose-Stra6(-/-) mice fed chow resulted in leanness, which may contribute to their increased insulin sensitivity. However, in wild-type mice with high-fat-diet-induced obesity and in ob/ob mice, the marked downregulation of STRA6 in adipocytes and adipose stromovascular cells does not compensate for obesity-associated insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.