ArticleThe Journal of physiology2014
Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Dual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain.Pain · 2026Article
- Optogenetic Approach for Investigating Descending Control of Nociception in Ex Vivo Spinal Cord Preparation.Bio-protocol · 2025Article
- Cell Type-Dependent Short-Term Plasticity and Dopaminergic Modulation of Sensory Synapses onto Mouse Superficial Dorsal Horn Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Central terminals of primary afferents coordinate the spontaneous activity of dorsal horn neurons.The Journal of physiology · 2025Article
- An electrophysiologist's guide to dorsal horn excitability and pain.Frontiers in cellular neuroscience · 2025Review
- Noise or signal? Spontaneous activity of dorsal horn neurons: patterns and function in health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- Approach for Electrophysiological Studies of Spinal Lamina X Neurons.Bio-protocol · 2024Article
- Contralateral Afferent Input to Lumbar Lamina I Neurons as a Neural Substrate for Mirror-Image Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Quantitative spatial analysis reveals that the local axons of lamina I projection neurons and interneurons exhibit distributions that predict distinct roles in spinal sensory processing.The Journal of comparative neurology · 2022Article
- Precision spinal gene delivery-induced functional switch in nociceptive neurons reverses neuropathic pain.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Elucidating afferent-driven presynaptic inhibition of primary afferent input to spinal laminae I and X.Frontiers in cellular neuroscience · 2022Article
- Spontaneous Multimodal Neural Transmission Suggests That Adult Spinal Networks Maintain an Intrinsic State of Readiness to Execute Sensorimotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons.Scientific reports · 2019Article
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- Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons.Scientific reports · 2018Article
- Analysis of spontaneous activity of superficial dorsal horn neurons in vitro: neuropathy-induced changes.Pflugers Archiv : European journal of physiology · 2016Article
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- Influence of emotional states on inhibitory gating: animals models to clinical neurophysiology.Behavioural brain research · 2015Review
- Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal lamina I is a key element of the pain processing system which relays primary afferent input to supraspinal areas. However, little is known about how the signal is modulated by its intrinsic network including local-circuit neurones (LCNs) and much less numerous anterolateral tract projection neurones (PNs). Here, we used whole-cell patch clamp recordings in an isolated spinal cord preparation to examine properties of identified LCNs (n = 85) and PNs (n = 73) in their functionally preserved local networks. Forty LCNs showed spontaneous rhythmic firing (2-7 Hz) at zero current injection, which persisted in the presence of blockers of fast synaptic transmission. In the remaining cases, most LCNs and PNs fired tonically in response to depolarizing current injections. We identified LCNs and PNs receiving low-threshold primary afferent-driven inhibitory inputs, which in many cases were disynaptic and temporally preceded classical high-threshold excitatory inputs. This direct inhibitory link between low-threshold afferents and PNs can function as a postsynaptic gate controlling the nociceptive information flow in the spinal cord. The LCNs were found to be integrated into the superficial dorsal horn network by their receipt of monosynaptic and disynaptic inputs from other lamina I and II neurones. One-third of LCNs and two-thirds of PNs tested responded to substance P application. Thus, substance P released by a noxious afferent stimulation may excite PNs in two ways: directly, and via the activation of presynaptic LCN circuitries. In conclusion, we have described important properties of identified lamina I neurones and their roles in a new circuit for gating pain responses.
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