ArticleClinical oral investigations2014
Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Regulatory T Cells Across Oral Diseases: A Narrative Review on a Functional Perspective.International journal of molecular sciences · 2026Review
- Crosstalk Between Keratinocytes and T Cells in Ulcerative Oral Mucosal Diseases: Mechanisms of Epithelial Dysfunction and Therapeutic Perspectives.Journal of inflammation research · 2025Review
- What can we learn from treatments of oral lichen planus?Frontiers in cellular and infection microbiology · 2024Review
- Perspectives on salivary cytokines as noninvasive biomarkers for monitoring disease activity and therapeutic response of oral lichen planus.Journal of dental sciences · 2023Article
- A potential reciprocal emergence of regulatory T cells in oral lichen planus and pemphigus vulgaris: A meta-analysis.Journal of dental sciences · 2023Article
- Regulatory T cell therapy suppresses inflammation of oral mucosa.Frontiers in immunology · 2022Article
- Addisonian-like acrofacial hyperpigmentation following long-term hydroxychloroquine therapy in oral lichen planus.BMJ case reports · 2021Article
- Repurposing Chloroquine Against Multiple Diseases With Special Attention to SARS-CoV-2 and Associated Toxicity.Frontiers in pharmacology · 2021Review
- A systematic review and meta-analysis study of salivary and serum interleukin-8 levels in oral lichen planus.Postepy dermatologii i alergologii · 2018Article
- Foxp3, Regulatory T Cell, and Autoimmune Diseases.Inflammation · 2017Review
- Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus.Journal of translational medicine · 2016Article
- The Activation of NF-κB in Infiltrated Mononuclear Cells Negatively Correlates with Treg Cell Frequency in Oral Lichen Planus.Inflammation · 2015Article
- Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases.The Journal of antimicrobial chemotherapy · 2015Review
- Hydroxychloroquine in Dermatology and Beyond: Recent Update.Indian dermatology online journalArticle
- Role of Forkhead box protein 3 in the pathogenesis of oral lichen planus: A systematic review.Journal of oral and maxillofacial pathology : JOMFPReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRegulatory T cells (Tregs) have emerged as important mediators in inflammatory and autoimmune diseases. We investigated the possible involvement of Tregs in oral lichen planus (OLP) and the influence of clinical therapy (hydroxychloroquine and prednisone) on the frequencies of Tregs in OLP patients. MATERIALS AND
methodsOne hundred fifty patients diagnosed with OLP were the study cohort. Levels of Tregs in blood and tissues were detected using flow cytometry and immunostaining, respectively. Cytokine production was assessed using a proteome profiler array and determined by enzyme-linked immunosorbent assay. mRNA expression of transcription factors was detected by real-time quantitative PCR. Hydroxychloroquine or prednisone was used to treat patients randomly. The frequency of Tregs was detected before treatment and 2 weeks after treatment.
resultsCompared with healthy volunteers, OLP patients had a higher proportion of Tregs in serum and tissues before treatment (P < 0.001). Serum concentrations of interleukin (IL)-8, transforming growth factor (TGF)-β1, and IL-10 were significantly higher in patients than those in healthy controls. mRNA expression of Treg-related genes, including TGF-β, IL-10, signal transducer and activator of transcription 6, and GATA binding protein 3, were upregulated significantly in OLP patients. The frequency of Tregs was downregulated after hydroxychloroquine treatment.
conclusionsThese results suggest that Tregs may contribute to the immunopathogenesis of OLP and may provide a new therapeutic target for OLP treatment. CLINICAL RELEVANCE: T cell-mediated immune dysfunction may have a crucial role in OLP development. However, T helper 1 (Th1)/Th2 imbalance does not appear to be sufficient to understand the pathogenesis of OLP. This is the first study to show that Tregs are involved in the immunopathogenesis of OLP.
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